CNS Neoplasia Dogs Common Types Meningioma Astocytoma Oligodendroglioma Choroid plexus papilloma Lymphoma Neuroectodermal tumors Metastatic tumor CNS Neoplasia Dogs Dog has 118 months average survival time ID: 1039174
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1. CNS NeoplasiaToday’s Frontier
2. CNS Neoplasia- -DogsCommon TypesMeningiomaAstocytomaOligodendrogliomaChoroid plexus papillomaLymphomaNeuroectodermal tumorsMetastatic tumor
3. CNS Neoplasia- -DogsDog has 1-18 months average survival time1-3 with nothing6-9 with surgery12-18 with radiation treatmentAll tumors are invasive (malignant)
4. CNS Neoplasia- -CatsMost common is meningiomaUsually extra-axial and benignSeen in aged catsPresent with depression and dementia
5. Elvis
6. ElvisMRI revealed mass in the cerebral cortex
7. Elvis
8. TreatmentPrednisolone (0.25-0.5 mg/kg q12h)Treats secondary effectsCover with gastroprotectantsChemotherapyRadiation therapy
9. ChemotherapyLomustine60 mg/M2 givenMonitor CBC weeklyIf WBC and platelets okay in 5 weeks, then give 80 mg/M2Repeat every 5-8 weeksProcarbazine2-4 mg/kg/day for 1 week, then 4-6 mg/kg/dayMonitor CBCContinue as long as WBC levels are > 4000/µl & platelet count is > 100,000/µl
10. Chemotherapy5-hydroxyureaMeningiomas50 mg/M2 givenMonitor CBC weeklyRepeat every 3-4 weeksMelatoninGliomas0.1-0.2 mg/kg once a day in the eveningReduces growth of many tumors by 50%
11. TreatmentDietLow carbohydrateSupplementsAntioxidants & membrane stabilizersHerbal medicationsWestern- -Canine Cancer formulaTraditional Chinese medicine- -Stasis in the Mansion of the Mind
12. Blood StagnationHz:Acute SeizuresHead InjuryTongue red & greasyPulse Fast, wiry & slipperyRx Principleexpel phlegm, extinguish the wind, open the orifice, stabilize the seizures and invigorate bloodAPCV-15, ST-40, PC-5, HT-7, LI-11, LIV-3, An Shen, Da Feng MenTCM HerbalDing Xian WanTCVM Cancer Treatment
13. Stasis in Mansion of Mind Angelica Bai Zhi Warm the Channel, relieve pain Pinellia Ban Xia Transform phlegm Ligusticum Chuan Xiong Move Blood Salvia Dan Shen Move Blood Lumbricus Di Long Clear Wind, invigorate Channel Ligusticum Gao Ben Relieve pain Pueraria Ge Gen Bring Qi upward Carthamus Hong Hua Break down Blood Stasis Bombyx Jiang Can Transform phlegm, resolve nodule Scorpion Quan Xie Break down Blood Stasis Cimicifuga Sheng Ma Ascend Qi Fritillary Zhe Bei Mu Transform phlegm, resolve nodules Scolopendra Wu Gong Detoxify, resolve nodules
14. Max’s FormulaBai Zhi Angelica Clear Wind-Cold and relieve painDa Huang Rheum Clear stagnation/stasis and clear HeatJie Geng Platycodon Open the Upper Jiao and transform phlegmMu Li(Shu) Ostrea Soften hardness and clear massTian Hua Fen Trichosanthes Clear Heat and promote body fluidsXia Ku Cao Prunella Clear Liver Heat and resolve nodulesXuan Shen Scrophularia Clear Heat and cool BloodZhe Bei Mu Fritillaria Soften hardness and clear nodules
15. Wie Qi BoosterBai Hua She She Cao Oldenlandia Inhibit cell mutation and tumor growthBan Zhi Lian Scutellaria Inhibit cell mutation, inhibit tumor growthChen Pi Citrus Move Qi and transform phlegmDang Gui Angelica Tonifies BloodDang Shen Codonopsis Tonify Qi and boost Wei QiHuang Qi Astragalus Tonifies Qi in whole body and Wei QiWu Yao Lindera Move Qi and clear stagnationXuan Shen Scrophularia Cool Blood and nourish Yi
16. Stasis BreakerBai Hua She She Cao Oldenlandia Inhibit cell mutation and tumor growthBan Zhi Lian Scutellaria Clear Heat-toxin, inhibit cell mutation, inhibit tumor growthE Zhu Zedoaria Purge the interior, break Blood stasis and clear massMu Li(Shu) Ostrea Soften hardness and clear massSan Leng Sparganium Purge the interior, break stasis and clear massZhe Bei Mu Fritillaria Soften harness and clear nodules
17. Reba5 year old, German Shorthair PointerHistory of seizures starting 1 month priorResponsive to phenobarbitalTongue: purplePulse: fast & wiry
18. RebaNeurologic ExamMild dementiaCP deficits in both hind legsBabinski’s sign on left side of the bodyLocalizationCerebrum affecting both side (>right)
19. Reba- -1st CT scan
20. RebaDi Tan TangStasis in Mansion of MindWei Qi BoosterWestern herbs
21. Jerry10 year old, MxProgressive loss of coordination and head tiltPersonality changeTongue: purplePulse: fast & wiry
22. JerryNeurologic ExamLeft head tiltPositional, vertical nystagmusMild CP deficits in rear L>RXextensor R -> L in rearLocalizationL Cerebellar pontine angle with cerebral signs
23. JerryTCM Dx:Liver Blood StagnationTCM Rx:Stasis in Mansion of MindWie Chi Booster
24. Jerry- -MRI scan
25. Radiosurgery (3D radiation therapy)McKnight Brain Institute at UFHigh, single dose radiotherapy5 arcs of radiation provide sphere of deathBased upon the focal size and tissue treated
26. Radiosurgery- -TreatmentTreatment is applied with LINAC unit at UFBICost of radiosurgeryprocedure is around $3000.00 plus workup & conventional surgery
27. Radiosurgery SuccessOverall ED50 is around 13 monthsSome patients survive much longerPrognosis for meningiomas is better than others
28. Cancer RecommendationsLow-Carbohydrate food (home prepared is best or use Pedigree Weight Loss Formula)Canine basic antioxidant formula (Westlab Pharmacy 1-800-4WESTLA)Canine arthritis formula (Westlab)Canine cancer formula (Westlab)- -use at 2 times prevention doseCOX-2 inhibitor (daily- -particularly for carcinomas)Melatonin at night (0.1-0.2 mg/kg)
29. TCVM Brain CancerMax FormulaStasis in Mansion of MindWei Qi BoosterWestern herbsorandandTransports to Head
30. Wonderland
31. Thor7 year old M/C Rottweiller2 month history neck and back painMinimal response to carprofen
32. Thor
33. ThorLocalization of LesionDAMNNIIITTVOC1-T2 (particularly C6-T2 exramedullary)IVDD (Wobblers)MyelitisGMESpinal Tumor
34. ThorDifferential Dx?Diagnostic Approach?Treatment?PProblem ListNeck PainBack PainForeleg LamenessPosterior ParesisIVDDInfectionInflammationNeoplasia
35. Thor- -Diagnostic ApproachMDBCBCChemistry ProfileUAChest & Abdominal RadiographsAbdominal UltrasoundNeurologic TestsEMGCSF AnalysisCisternalLumbarMyelogram ± CT scanClient EducationP
36. Thor- -MDBUnremarkableO
37. Thor- -CT/Myelogram
38. Thor- -TL Myelogram
39. Thor- -TL CT
40. Thor- -Final DiagnosisCaudal Cervical IVDDLumbar NeoplasiaA
41. Thor- -Client EducationWithout aggressive surgery, chemotherapy or radiation therapy, the prognosis is poorMay continue to progress over 1-18 monthsTreat for pain as neededConsider CAVM & TCVM approaches to augment or instead of Western therapyP
42. Thor- -TCVM examTongueRed/purplePulseWeak bilaterallyFastSensitivityGB 21BL 18BL 23TCVM DiagnosisCombined Qi/Yin Deficiency with Blood Stagnation
43. Thor- -TCVM TherapyAPCervical pointsBL10GB 21Cervical Hua-tuo-jia-jiLumbar pointsBai HuiBL40BL62Cancer pointsTH 5GV14ST36LIV3HerbalMax Formula½ doseJing TangStasis in Mansion of Mind Formulafull doseJing TangHindquarter Formula½ doseJing Tang
44. Cervical NeoplasiaAcute or chronic progressive quadriparesisUsually has neck painOften in older animals
45. Cervical NeoplasiaAcute or chronic progressive quadriparesisUsually has neck painOften in older animals
46. Cervical NeoplasiaSurgery with follow up fractionated radiotherapy
47. Spinal Cord- -NeoplasiaNeurofibrosarcoma
48. Rudy
49. RudyLocalization of LesionOT3-L3 (close to T3)
50. Rudy- -MRIORR
51.