Atrial and Ventricular E lectrophysiology in Conscious Dogs Liomar A A Neves James Buening Jinbao Huang Peter B Senese Michael R Gralinski CorDynamics Inc Chicago IL ID: 1031271
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1. Dronedarone Effects on Atrial and Ventricular Electrophysiology in Conscious DogsLiomar A. A. Neves, James Buening, Jinbao Huang, Peter B. Senese, Michael R. GralinskiCorDynamics, Inc., Chicago, IL - www.cordynamics.comSummaryIntroductionObjectivesConclusionMethods30min 30min30min30minVehicleDRO 0.033 mg/kg/minDRO 0.067 mg/kg/minDRO 0.167 mg/kg/minAERP & VERP MeasurementsBlood samplesEffects of Dronedarone on Atrial Effective Refractory Period in Conscious Telemeterized Male Beagle DogsEffects of Dronedarone on Ventricular Effective Refractory Period in Conscious Telemeterized Male Beagle DogsEffects of Dronedarone on QTcVDW Interval and P-wave duration in Conscious Telemeterized Male Beagle DogsQTcVDWP-durationPlasma Concentration of Dronedarone during Continuous Infusion of Escalating Doses every 30 minutes in Conscious Telemeterized Male Beagle DogsEffects of Dronedarone on Arterial Blood Pressure in Conscious Telemeterized Male Beagle DogsSAPDAPMAP