1BackgroundofresearchChiralmoleculesareacategoryofmoleculeoftenfoundinpharmaceuticaldrugswhichexistintwoformseachbeingamirrorimageoftheotherDespitethesimilaritybetweenthetwomolecularformsthephys ID: 945789
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RATION WORLD-LEADING RESEARCHERS 1.BackgroundofresearchChiralmoleculesareacategoryofmolecule,oftenfoundinpharmaceuticaldrugs,whichexistintwoforms,eachbeingamirrorimageoftheother.Despitethesimilaritybetweenthetwomolecularforms,thephysicalandchemicalcharacteristicsareoftenverydifferent.Inthecaseofdrugs,thesedifferencesmayleadtooneformofthechiralmoleculebeingtherapeuticallybeneficial,whiletheotherformmaybephysiologicallyharmful.2.ResearchobjectivesThegoalofthisprojectistodevelopanimagingmethodthatcanvisualizebothformsofchiralmoleculesinsmallanimalssimultaneously.3.Researchcharacteristics(incl.originalityandcreativity)Thekeyfeatureofthisprojectistochemicallylabelthetargetchiralmoleculeswithmarkerscontainingunpairedelectrons.Energyabsorption
bytheunpairedelectronscanbeusedtodistinguishthetwoformsoflabeledmolecules.Visualizationofthetimedependentdistributionoflabeledchiralmoleculeswillbeperformedinsmallanimals.4.AnticipatedeffectsandfutureapplicationsofresearchSincechiralmoleculesareoftenusedasdrugs,theabilitytovisualizetheirbehaviorinlivingtissues,wouldbeofgreatbenefitinthefieldsofbiology,medicine,andpharmaceuticalscience. Project TitleMolecular imaging based on magnetic resonance of chiralmoleculesiroshi HIRATAHokkaido University How does chirality of molecules affect their pharmacokinetics in Chirality of drugs can determine Labels with unpaired electrons are attached to the target molecules, and the labels can Markers shown in red and blue.Example of two chiral molecul
es labeled with unpaired electron markers 14N 15N We need a method to simultaneously visualize two forms of a chiral molecule A molecular characteristic most often caused by the inclusion of an non-symmetric carbon atom. Molecules which exist in two non-super imposable forms like a mirror image, similar to the hands in the photo above.How to visualize two kinds of molecules? Mirror images (2) Chemical labeling of chiral electron markers and confirmation of chiral molecule properties (3) Simultaneous imaging of the pharmacokinetics of two forms of labeled chiral molecules(1) General concept –The simultaneous imaging of chiral molecules using magnetic Novel concept Visualization technologiesImaging of chiral drug Study of diseas