Compared to agematched nonpregnant individuals pregnant women are at increased risk of hospitalization 3fold adjusted RR of needing intensive care 105 vs 391000 cases and mechanical ventilation ID: 1033210
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3. COVID19 Infection in PregnancyCompared to age-matched, non-pregnant individuals, pregnant women are at increased risk of hospitalization3-fold adjusted RR of needing intensive care (10.5 vs 3.9/1000 cases) and mechanical ventilation (2.9 vs 1.1/1000 cases)
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10. Current Society Recommendations re: Vaccination:CDC/ACIP, SMFM, ACOG, ASRM all agreeVaccine should be offered (if would be offered without pregnancy)Women who decline should be supported (for women who decline discuss postpartum vaccination)Theoretical risk of vaccines is low: Pfizer and Moderna: Minimal circulation of the lipid nanoparticles (we think); mRNA is large, highly charged, and degraded rapidly-extremely unlikely to interact with placentaJohnson and Johnson: The same adenovirus vector platform has been used for other clinical vaccines in pregnant people, including Ebola, HIV, and RSV adenoviral vaccine studies, with no adverse pregnancy outcomes
11. Lactation Summary: ACOG, SMFM, ACIPShould be offeredSlightly stronger language re: safety and encouraging vaccinationi.e. SMFM “recommends”No need to delay or interrupt breastfeeding