MR Microscopy From Methods in Molecular Medicine Vol - PDF document

MR Microscopy61 MR Microscopy63turn microcoils) are reduced, eddy currents in the wire reduce its effectiveis used for tuning the circuit, whereas a capacitor in series is used for impedance matching. 64Gimiing design requirements in our ensuing discussing of microcoil design. It should MR Microscopy67 MR Microscopy71 12á*TSusceptibility mismatches create local field inhomogeneity and increaselinewidth, resulting in signal attenuation from line broadening.These susceptibility effects can be undesirable and can lead to poor imagequality, or they can provide a valuable signature of the sample. Field distor-tions arising from cellular boundaries can be distinguished in gradient-echoexperiments, providing a useful tool for microscopy of cell and tissue constructs.2.3.1.1. TECHNICALFor a given pixel, if the field variation caused by susceptibility is less thanthe variation caused by the gradient, susceptibility does not have an effect onimage quality. Therefore, susceptibility effects are overcome by using largegradients, such that: MR Microscopy73 rDTacqfore, diffusion from random-phase fluctuation impedes on resolution only whenbe applied to overcome phase dispersion and signal loss from diffusion. MR Microscopy75 76Gimitransplant function, one must thoroughly understand cellular response to drugs, 78Gimihigh-resolution spatial resolution with high-resolution biochemical information. MR Microscopy8123.Gimi, B., Eroglu, S., Leoni, L., Desai, T. A., Magin, R. L., and Roman, B. (2003)24.Massin, C., Boero, G., Vincent, F., Abenhaim, J., Besse, P.-A., and Popovic, R. S.25.Massin, C., Eroglu, S., Vincent, F., et al. (2003) Planar microcoil-based magnetic26.Roemer, P. B., Edelstein, W. A., Hayes, C. E., Souza, S. P., and Mueller, O. M.27.Sodickson, D. K. and McKenzie, C. A. (2001) A generalized approach to parallel28.Wright, S. M., Magin, R. L., and Kelton, J. R. (1991) Arrays of mutually coupled29.Sodickson, D. K. and Manning, W. J. (1997) Simultaneous acquisition of spatial30.Pruessmann, K. P., Weiger, M., Scheidegger, M. B., and Boesiger, P. (1999)31.Sodickson, D. K., McKenzie, C. A., Ohliger, M. A., Yeh, E. N., and Price, M. D.32.Lin, W.-C. and Fedder, G. K. (2001) 33.Seeber, D. A., Hoftiezer, J. H., and Pennington, C. H. (2002) Pulsed current gra-34.Bowtell, R. and Robyr, P. (1998) 35.Zhang, H. and Cory, D. G. (1998) Pulsed gradient NMR probes for solid state36.Seeber, D. A., Hoftiezer, J. H., Daniel, W. B., Rutgers, M. A., and Pennington, C.37.Glover, P. M. and Mansfield, P. (2002) Limits to magnetic resonance microscopy.38.Gimi, B., Leoni, L., Braun, M., Eroglu, S., Magin, R. L., and Roman, B. (2003) MR Microscopy8355.Duong, T. Q., Sehy, J. V., Yablonskiy, D. A., Snider, B. J., Ackerman, J. J., and56.Sehy, J. V., Banks, A. A., Ackerman, J. J., and Neil, J. J. (2002) Importance of57.Sehy, J. V., Ackerman, J. J., and Neil, J. J. (2002) Evidence that both fast and58.Francis, K. and Palsson, B. O. (1997) Effective intercellular communication dis-59.Minard, K. R. and Wind, R. A. (2002) Picoliter (1)H NMR spectroscopy. 60.Grant, S. C., Aiken, N. R., Plant, H. D., et al. (2000) NMR spectroscopy of single62.Hsu, E. W., Aiken, N. R., and Blackband, S. J. (1996) Nuclear magnetic reso-63.Sehy, J. V., Ackerman, J. J., and Neil, J. J. (2001) Water and lipid MRI of the64.Schoeniger, J. S., Aiken, N., Hsu, E., and Blackband, S. J. (1994) Relaxation-time65.Jacobs, R. E., Papan, C., Ruffins, S., Tyszka, J. M., and Fraser, S. E. (2003) MRI:66.Jacobs, R. E. and Fraser, S. E. (1994) Magnetic resonance microscopy of embry-67.Smith, B. R., Linney, E., Huff, D. S., and Johnson, G. A. (1996) Magnetic reso-68.Smith, B. R., Johnson, G. A., Groman, E. V., and Linney, E. (1994) Magnetic69.Louie, A. Y., Huber, M. M., Ahrens, E. T., et al. (2000) In vivo visualization of70.Johnson, G. A., Benveniste, H., Engelhardt, R. T., Qiu, H., and Hedlund, L. W.71.Ahrens, E. T., Laidlaw, D. H., Readhead, C., Brosnan, C. F., Fraser, S. E., and