Download presentation
1 -

Quality in Life Wellness and Community


Dear ReadersThis month it is 3 years since we officially opened the Knoebel Institute and moved into our gorgeous new building Betty and Fritz Knoebelaging institute at DU is coming into fruitionIn th

belinda's Recent Documents

equired to retametals purchased for at least five working days and ret
equired to retametals purchased for at least five working days and ret

ious metal dealer in Lebanon County you must beend of the next business dayare to be emailed to ch501lebcntyorgPRECIOUS METALS UNITLebanon County DistrictAttorneys Office formed thePrecious Metals Uni

published 2K
Guide forReviewing STOP Subgrantee ReportsFor Administrators of the ST
Guide forReviewing STOP Subgrantee ReportsFor Administrators of the ST

This project was supported by Grant No 2017AXK059 awarded by the x0000x0000GUIDE TO REVIEWING SUBGRANTEE REPORTSTable of ContentsPurpose of this Document 1Administrator Responsibilities To Subgrantees

published 0K
DEPARTMENT OF TRANSPORTATION
DEPARTMENT OF TRANSPORTATION

1401 EAST BROAD STREETRICHMOND VIRGINIA 23219Stephen BrichCommissionerVirginiaDOTorgWE KEEP VIRGINIA MOVINGMEMORANDUMTONew Products ApplicantsFROMVDOT New Products CommitteeSUBJECTNew Products Applica

published 0K
Coming Together and Staying Safe
Coming Together and Staying Safe

The Redeemer CommunityThe Wider ChurchThe Community BeyondPrayers PersonalsGetting Ready for SundayOUR CONGREGATIONMinisters -All who gather here in the name of JesusPastor Rev David ShullOffice Mana

published 0K
City of Garden Grove  First Time Homebuyer Guidelines
City of Garden Grove First Time Homebuyer Guidelines

112x001cx001c101CTOFARDENROVEFRSTTMEOMEBUERPRORAMFORMANUFACTUREDOUSNCity of Garden Grove First Time Homebuyer Guidelines 112x001cx001c101CTOFARDENROVEFRSTTMEOMEBUERPRORAMFORMANUFACTUREDOUSNTAB/EOFCON

published 0K
primer for alkaline or porous substrates
primer for alkaline or porous substrates

PreludeSOLVENT FREE BLOCKS SURFACE PH LOW ODOR Prelude fs an acovifc x0066006Cllo poepaoatfln slirtfln aesfgnea tl fmpolse x0066006Cllofng srbstoates befloe tee appifcatfln lf x0066006Cllo-clseo

published 1K
Name of Applicant x MCxID 3x 000x MCxID 3x 000x MCxID 4x 000x MCxI
Name of Applicant x MCxID 3x 000x MCxID 3x 000x MCxID 4x 000x MCxI

reduce our towns carbon footprint x /MCxID2x1 00x /MCxID2x1 00x /MCxID 2x2 00x /MCxID 2x2 00x /MCxID 2x3 00x /MCxID 2x3 00nd and bring eco-friendly options to our schools and community at large

published 0K
This form is authorized as outlined under the tax or fee Act imposing
This form is authorized as outlined under the tax or fee Act imposing

Mail your completed form with any required attachments and payment toCENTRAL REGISTRATION DIVISION ILLINOIS DEPARTMENT OF REVENUEPO BOX 19030 SPRINGFIELD IL 62794-9030Step 4 Sign below - Schedule RE

published 0K
Download Section

Download - The PPT/PDF document "" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.






Document on Subject : "Quality in Life Wellness and Community"— Transcript:

1 Quality in Life, Wellness and Community
Quality in Life, Wellness and Community Dear Readers, This month it is 3 years since we officially opened the Knoebel Institute and moved into our gorgeous new building. Betty and Fritz Knoebel ’ aging institute at DU is coming into fruition! In these 3 years, we have secured $4.7 million in external research grants, and we have brought in more than $1 million in donations. KIHA has recruited 10 research groups, which are focused on dementia and movement disorders, healthy aging, financial security and aging, intergenerational programs and much more. KIHA is truly an interdisciplinary place, with collaborations with 9 other colleges at DU, and with researchers in 10 different countries and 12 US states. This hard work and expansive growth could not have been done without the many supporters and collaborators both within A heartfelt thank you goes out to Dr. Lynn Taussig, who implemented KIHA, and to all of you who have helped us build a first class research and outreach program focused on Healthy Aging!! We are still growing and need your help to expand successful programs at KIHA. attend some of our many events and research seminars. New to this year is the KIHA Mindfulness class that, both in the spring and fall. The instructor, Kara Traikoff, is a Professor in the Language Department at DU and this fall is her second time teaching this class at KIHA. Tai Chi classes , led by Jean Gan, who teaches in communities throughout Metro Denver. Our Tai Chi group has now been carrying on for 2.5 years and is a popular activity in our community as well as among DU faculty and students. If you are interested in either of these activities, please contact us (aging@DU.edu). We also organize monthly ” chalk talks ” which are scientific faculty seminars, as well as monthly Grand Rounds where we invite prominent scientists from around the world. Hope

2 to see you all soon! Dr. Lotta Gran
to see you all soon! Dr. Lotta Granholm - Bentley, PhD/DDS Executive Director November 2019 Newsletter From the Director KIHA short report in numbers Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 2 KIHA researchers have implemented research in these areas: • Memory loss and aging • Movement Disorders • Intergenerational Programs • Financial Security and aging • Gerotechnology KIHA faculty have collaborated with 28 other DU faculty, located in 13 different departments and 9 different colleg- es. These interdisciplinary collaborations have resulted in close to 50 publications by KIHA faculty, affiliated fac- ulty and collaborators since the inception in 2016. We have active collaborations with 9 colleges at DU. KIHA Transformative Directions Outside Collaborations KIHA faculty are collaborating with many other Universities. During the last 3 years, KIHA faculty have collaborated with 53 other researchers from out- side DU, and KIHA - affiliated faculty add another 13 active collaborations to that list. KIHA faculty currently have col- laborations in 13 different US states and in 10 different coun- tries (see Map ). Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 3 Focus on Research: Putting DU on the map A new network of researchers is working to expand knowledge and treatment for those with Down syn- drome and Alzheimer ’ s disease. People with Down syndrome live longer lives than ever before and develop Alzheimer ’ s disease in their 40s or 50s. More than 300,000 people live with Down syndrome in the USA alone, and yet few treat- ments exist for their age - related dementia. The Biobank consortium is lead by Dr. Granholm and includes 11 sites, 3 in Europe and the rest in 7 states in the US (see below) This consortium has received a 5 - year infrastruct

3 ure grant from the Bright Focus foundat
ure grant from the Bright Focus foundation and 3 different grants from the National Institutes of Health to conduct mechanistic re- search on samples from those with Down syndrome. Hunt Potter CU Anschutz Eric Hamlett MUSC Steve Carroll MUSC Juan Fortea Barcelona Aurelie Ledreux DU Martin Margittai DU Liz Head UC Irvine Elliott Mufson Barrow NI Agneta Nordberg Karolinska Inst. Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 4 Prominent Visitors YALE FAMILY FOUNDATION SCHOLAR May 2019 Dr. Ira Lott | Professor & Chair | Pediatrics School of Medicine | UC Irvine Dr. Lott is a child neurologist at the Uni- versity of California, Irvine and Children ’ s Hospital. He served as a Clinical Re- search Associate at the National Institute of Child Health and Human Development. He was on the faculty at Harvard Medical School as Clinical Director of the Eunice Kennedy Schriver Center for Mental Retardation from 1974 - 1983. Dr. Lott is one of the foremost experts in the world on Down Syndrome and shared a life - time of re- search with KIHA scientists and community members. He is a long - time collaborator and friend of Dr. Granholm ’ s. Dr. Lott visits the KIHA labs together with Ms. Michelle Whit- ten, President & CEO, Co - Founder of the Global Down Syn- drome Foundation in Denver. Dr. Stan Prusiner Visit Dr. Stanley Prusiner with Drs. Granholm, Mar- gittai, Ledreux and Condello. Dr. Stanley Prusiner, MD, is the director of the Institute for Neurodegenerative Dis- eases at University of California, San Francisco (UCSF). He discovered prions, a class of infectious self - reproducing path- ogens that can spread independently. Dr. Prusiner received the Nobel Prize in Physiology or Medicine in 1997. He continues to work with Prion diseases and has recently proposed that Alzheimer ’ s disease is a double prion disorder. D

4 r. Prusiner and his close collaborator
r. Prusiner and his close collaborator Dr. Carlo Condello spent a day at the Knoebel Institute in October this year to establish a collabo- ration with KIHA investigators. Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 5 New scientist joins KIHA and NSM In the summer of 2019, Dr. Sunil Kumar joined University of Denver as a tenure - track Assistant Professor in the Department of Chemistry and Biochemistry, and a faculty member of the Knoebel Institute for Healthy Aging. Dr. Kumar came to us from New York University (NYU) where he was a senior postdoctoral fellow in Prof. Andrew Hamilton ’ s laboratory, who is the 16 th president of NYU campuses worldwide and his work is focused on molecular control of structure and reactivity of new compounds to be used to treat cancer, Alzheimer ’ s disease and other pathologies. Sunil re- ceived his PhD from Clemson University in South Carolina in 2011 and then proceeded to a postdoctoral position at Yale University, followed by NYU. His work is focused on the design of artificial protein mimetics to investigate the oligomerization and aggregation of proteins in- volved in amyloid relevant pathologies including neurodegenerative disorders and or- gan localized diseases. His laboratory and office space are located in KIHA. We are happy that Sunil has joined us, leading to natural collaborations with most research groups at KIHA and in the Chemistry Department. Recent publications : Maity D, Kumar S, Curreli F, Debnath AK, Hamilton AD. α - Helix - Mimetic Foldamers for Targeting HIV - 1 TAR RNA. Chemistry. 2019 May 28;25(30):7265 - 7269. doi: 10.1002/chem.201900139. Epub 2019 Apr 10. PMID: 30825250. Lee CH, Yu JR, Kumar S, Jin Y, LeRoy G, Bhanu N, Kaneko S, Garcia BA, Hamilton AD, Reinberg D. Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin. Mol Cell. 2018 May 3;70(3):422 -

5 434.e6. doi: 10.1016/ j.molcel.2018.03.0
434.e6. doi: 10.1016/ j.molcel.2018.03.020. Epub 2018 Apr 19. PMID: 29681499. DU Academia Industry Alliance Connecting Graduate Students with Industry Who We Are The University of Denver ’ s Academia Industry Alliance is an or- ganization of primarily graduate students and postdoctoral researchers who aim to hold networking events, including quarterly happy hours, in an effort facilitate rela- tionships between these academic individuals and industry members - including en- trepreneurs, companies, and other staff within fields pertaining to science, technol- ogy, engineering, and mathematics (STEM) Our Goal We hope to offer a work force and academic perspective for individuals in industry - related STEM fields, educate academic members about career opportunities, and ultimately bridge the gap between academia and industry Find Out More Our first event will be a Holiday Party Charity Toy Drive on December 5 th at Live @ Jack ’ s . This is hosted in collaboration with University of Colorado ’ s Academia In- dustry Alliance . Please email dunetworkingnerds@gmail.com for more info and to inquire about being added to the guest list. KIHA in the Community Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 6 Jayla Sanchez - Warren, Director of the Area Agency on Aging at Denver Regional Council of Governments, Lt Gov. Dianne Primavera, and Dr. Lotta Granholm - Bentley The Seniors ’ Resource Center (SRC) is the Denver area ’ s largest non- profit dedicated to services for older adults and those with developmental dis- abilities. On September 12, the SCR held its annual fundraising luncheon. Among the speakers were the SRC board chairman, Robert Hayes, the SRC President Chris Lynn, as well as the Lt. Governor, Dianne Primavera. Parkinson ’ s 2.0 Translating science into treatment The Movement Disorders Foundation and KIHA co -

6 hosted a community education event on O
hosted a community education event on October 5 about the latest work in research for this difficult neu- rological condition. Dr. Rajeev Kumar (MD, Rocky Mountain Movement Disorders ’ Center), Dr. Daniel Paredes (KIHA) and Dr. Brian Berman (MD, CU An- schutz Movement Disorder Center) shared their views on current as well as future treatment options. More than 160 attendees attended the event. If you are interested in these or other education events please contact us at aging@du.edu Walk to End Alzheimer ’ s Team KIHA Pioneers KIHA faculty are dedicated to finding a cure for Alzheimer ’ s disease through our translational research. Staff and students support this dedication in a myriad of ways. All were happy to participate in the annual walk for the Alzheimer ’ s Association to raise awareness and funds for Alzheimer's disease. On Saturday, September 14, the KIHA Pioneers Team gathered at 7:30 am in Denver ’ s City Park to participate along with 12,000 other participants. KIHA extends a hearty THANK YOU to all who supported us by joining our team, walking with us, or donating and thank you to our Team captain, Sarah Thomas. Thanks to you we raised more than $3,400, exceeding our team goal and close to 40 people signed up to be on the KIHA PIONEER team! KIHA in the Community Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 7 Walk to Defeat ALS | Team ALS Pioneers Amyotrophic Lateral Sclerosis (ALS), or better known as Lou Gehrig ’ s disease, is a rapidly progressive and fatal neurodegenerative disease which causes one to lose the ability to walk, speak, and breathe. On average, 15 cases of ALS arise with each day and those living with ALS have an average life expectancy of only 2 - 5 years. There are no known causes for ALS and treatments are limited. Through our research at KIHA, we are devoted to increa

7 sing our understanding about ALS and to
sing our understanding about ALS and to finding cures and treatments. The ALS Pioneers team raised $1,355 and helped to contribute to the $325,000 total raised. These funds help to spread awareness about ALS, support people with ALS, and to find cures. On Sunday, October 13th, the ALS Pioneers Team gathered at 9 am in Denver ’ s Sloan ’ s Lake Park to participate along with 2,000 other participants. KIHA extends a hearty THANK YOU to all who supported us by joining our team, walking with us, or donating. Please join us for next year ’ s ALS or Alzheimer walks! Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 8 Kara Traikoff has been a part of the DU community for 10 years. Kara is a mindfulness instructor and coach trained through the Center for Mindfulness at UMASS Medical School. Participants practice mindfulness in a variety of forms. The class involves experiential learning and open dialogue around individual experiences. MBSR was originally developed by Dr. Jon Kabat - Zinn at UMASS. A new class will begin in January of 2020. KIHA in the Community 2019 marks the third year that KIHA offers Tai Chi! In 2019, Tai Chi will be held on Fridays from noon until 1 pm in the ECS fifth floor event space . Join KIHA ’ s instructor Jean Gan, who is a physical therapist and has taught Tai Chi for more than seven years. Jean teaches Yang and Sun styles. She is convinced that Tai Chi is a huge benefit to healthy aging! Everyone is welcome, regardless of age or previous knowledge in Tai Chi. Drop by to learn or deepen your practice with others. If you have questions, email aging@du.edu. KIHA Mindfulness Based Stress Reduction Class MBSR KIHA Offers Tai Chi to All Tai Chi instructor Jean Gan How can you help? KIHA scientists are very successful in grant funding but every Institute need

8 s support from its community. Here are
s support from its community. Here are im- portant areas for support: • Graduate student scholarships • Faculty recruitment • Equipment For more information, please contact Valerie Appelbaum valerie.appelbaum@du.edu or 303 - 871 - 4056 Knoebel Institute for Healthy Aging | November 2019 Newsletter | page 9 Recent Publications 1. Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B , Granholm A - C, and Ledreux A . (2018) Altered levels of plasma neuron - derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019 Jan 3:fj201802319R. doi: 10.1096/ fj.201802319R. [Epub ahead of print] PMID: 30605353. 2. Chess E . and Greenfield J. Bridging the Gap Between Cognitive Health and Financial Capacity in Older Adults: A Scoping Review - 2019 GSA Annual Scientific Meeting (to be submitted as peer - reviewed article as well). 3. Ledreux A , Håkansson K, Carlsson R, Kidane M, Columbo L, Terjestam Y, Ryan E, Tusch E, Winblad B, Daffner K, Granholm AC , Mohammed AKH.Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults. J Alzheimers Dis. 2019;71(4):1245 - 1261. doi: 10.3233/JAD - 190756. 4. Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC . Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 Jul;79(7):639 - 655. doi: 10.1002/dneu.22712. Epub 2019 Aug 6. Review. 5. Goetzl EJ, Ledreux A, Granholm AC , Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron - Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy. Front Neurosci. 2019 May 8;13:452. doi: 10.3389/fnins.2019.00452. eCollection 2019. 6. Ren M, Hu Z, Chen Q, Jaffe A, Li Y, Sadashivaiah V, Zh

9 u S, Rajpurohit N, Heon Shin J, Xia W, J
u S, Rajpurohit N, Heon Shin J, Xia W, Jia Y, Wu J, Lang Qin S, Li X, Zhu J, Tian Q, Paredes D , Zhang F, Hong Wang K, Mattay VS, Callicott JH, Berman KF, Weinberger DR, Yang F.KCNH2 - 3.1 mediates aberrant complement activation and impaired hippocampal - medial prefrontal circuitry associated with working memory deficits. Mol Psychiatry. 2019 Sep 30. doi: 10.1038/s41380 - 019 - 0530 - 1. [Epub ahead of print]. Recently Awarded Grants 1. R01AG061566 - Granholm/Margittai/Mufson (Multi PIs) - 02/01/2019 - 11/30/2023 NIH/NIA Tau pathology in Down syndrome - related Alzheimer ’ s disease. 2. R21AG056974 - Granholm (PI) - 07/15/2017 - 03/31/2020 NIH/NIA “ Biological Correlates of Alzheimer in Down Syndrome ” Our project is focused on a novel biomarker method which can accurately diagnose AD in DS, as well as the Tau seeding capacity in samples from those with DS, based on previous experiments in idiopathic AD. Role: PI 3. R56AG055596 - Head (PI) Granholm subcontract - 09/30/2018 - 08/31/2019 NIH/NIA (subcontract) mTOR Activation and the Pathogenesis of Alzheimer Disease in Down Syndrome. Role: Subaward PI 4. CA2018010 - Granholm (PI) 10/01/2017 - 09/30/2022 Bright Focus Foundation International Brain Bank for Down syndrome - related Alzheimer's disease 5. Aurelie Ledreux PI : Brain - derived exosomes as biomarkers for Alzheimer's disease2018 Alzheimer ’ s Association Research Grants (AARG) - $149,997 over 3yearsCan measuring tau and beta - amyloid content in blood predict the development of Alzheimer's? 6. Ledreux and Linseman PIs : “ Alumia Pilot Data Grant ” 10/01/2019 – 09/30/2020. $57,000 total costs. 7. Linseman PI : “ Collaborative studies on TBI between KIHA and Resilience Code ” 10/01/2019 – 09/30/2021 $41,500 total costs. New Publications and Awarded Gran