Complications of Immune Response Over Stimulation CytokineProduction Inhibitors Calcineurin Inhibitors Signal 1blockers Costimulation Blockers CD28blockers Signal 2blockers CytokineFunction Inhibitors ID: 934496
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Slide1
Slide2Immune Response
Cellular and Humoral Immunity
Slide3Slide4Slide5Slide6Complications of Immune Response Over Stimulation
Slide7Slide8Slide9Slide10Slide11Slide12Slide13Cytokine-Production Inhibitors
(
Calcineurin
Inhibitors)
Signal 1-blockers
Slide14Slide15Slide16Slide17Co-stimulation Blockers
(CD28-blockers)
Signal 2-blockers
Slide18Slide19Slide20Cytokine-Function Inhibitors
(
mTOR
inhibitors)
Signal 3-blockers
Slide21Slide22Slide23Antimetabolities
Slide24Slide25Slide26Antibodies
Slide27Slide28Slide29Slide30Slide31Slide32Slide33Corticosteroids
Slide34Slide35Slide36Slide37Sites of Action of
Immunosuppressants
Slide38Slide39Slide40Slide41Slide42Checklist:
Describe the primary features of cell-mediated and humoral immunity.
Name 7
immunosuppressants
and, for each, describe the mechanism of action, clinical uses, and toxicities.
Describe the mechanisms of action, clinical uses, and toxicities of antibodies used as
immunosuppressants
.
Identify the major cytokines and other
immunomodulating
agents and know their clinical applications.
Describe the different types of allergic reactions to drugs.
Slide43Which of the following drugs specifically inhibit
calcineurin
in the activated
T -lymphocytes?
A
.
Daclizumab
.
B
.
Tacrolimus
.
C
. Prednisone.
D
.
Sirolimus
.
E
.
Mycophenolate
mofetil
.
Slide44