Why Would A Cell Divide Growth Repair The Cell Cycle Mitosis and Meiosis New cells can only be made when existing cells divide All cells have the ability to divide but some cells lose this ability ID: 475186
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Slide1
All Cells Come From CellsSlide2
Why Would A Cell Divide?
Growth
RepairSlide3
The Cell Cycle, Mitosis, and
Meiosis
New cells can only be made when existing cells divide. All cells have the ability to divide – but some cells lose this ability.
Intestinal epithelial lining - replaced every five days by cell division
Liver
cells - divide only to repair damage, and then stop dividingMeristem cells (tips of roots and shoots) – divide to produce new
growthSlide4
In eukaryotic cells, there are two types of cell division –
mitosis
and meiosis.
Mitosis is used to produce new cells for growth and repair. Meiosis is used in the formation of gametes (sex cells) only. In prokaryotes (bacteria), cell division does not involve mitosis or meiosis – bacteria reproduce asexually, by a type of cell division termed by binary fission.
The cell cycle is the process that all body cells from multicellular organisms use to grow and divide. The cell cycle starts when a cell has been produced by cell division and ends with the cell dividing to produce two identical cells.Slide5Slide6Slide7
Reproduction
Asexual reproduction - Mitosis
Produces offspring that inherit all their genetic material from just one parent
Ex – Paramecium and Sponges
Sexual reproduction - MeiosisGenetic material from each of two parents combinesEx: Most animals (Including you)Slide8
Reproduction in bacteria
Binary
Fision
(Bacteria)Slide9
MITOSIS
(M)
Process by which a
nucleus
divides into two – each with an identical set of chromosomes – the nuclei are genetically identical
Four phases – prophase, metaphase, anaphase, and telophase
Followed by cytokinesis – division of the cell into two genetically identical daughter cells
INTERPHASE
Period of cell growth; cell prepares cell for cell division (mitosis); genetic material (DNA) is copied and checked for errors – prevents mutations being passed on
No apparent activity
New organelles and proteins are made
Divided into three phases (G1, S, and G2 phase)
CELL
CYCLE
G1
S phase
G2
Mitosis (M)
Two daughter cells – genetically identicalSlide10
The Cell Cycle
Mitosis : Cell division in which two cells, with the same number of chromosomes identical to the parent, are produced from one cellSlide11
Most
cells in the
Human body have
46 chromosomes
with
23 pairsSlide12Slide13
G1 + S + G2 = INTERPHASE
No apparent observable activity
Cytokinesis – cell divides into two
DNA content = 20
G1
-
First growth phase – longest phase
Protein synthesis – cell “grows”
Most organelles producedVolume of cytoplasm increasesCell differentiation (switching on or off of genes)Length depends on internal and external factors
If cell is not going to divide again it remains in this phase
DNA content =
23
(
arbitary
)
S -
Replication phase
DNA replication – this must occur if mitosis is to take place
The cell enters this phase only if cell division is to follow
DNA content =
46
G2 -
Second growth phase - short
Short gap before mitosis (cell division)
Cytoskeleton of cell breaks down and the protein microtubule components begin to reassemble into spindle fibres – required for cell division
DNA content =
46
The Cell CycleSlide14
I P M A T
I Pro MatSlide15
Interphase
Up to 90% of a cells time is here
Normal cell functions:
Producing energyProducing enzymesG
1 phase – cell growsS phase – genetic material replicatesG2
phase – prepares for mitosisSlide16
Centrioles
show up
Cell is in the
first stage of mitosis.Slide17
Prophase (1
st
phase)
Centrioles divide and go to opposite sides of the cellSpindle fibers – appear from the centrioles and stretch to both poles
Nuclear envelope breaks down Nucleolus disappears (this results in what organelle no longer being produced?)Slide18Slide19
Metaphase (2
nd
Phase)
Chromosomes attach to spindle fibersChromosomes migrate to the center of the spindle fibersSlide20
Anaphase (3
rd
phase)
Centromeres separateEach
sister chromatid = 2 daughter chromosomes (move to the poles)Slide21
Telophase (4
th
Phase)
Spindle fibers disappearNuclear envelopes reformDaughter chromosomes begin to uncoil
Nucleolus reforms – protein production returnsCytokinesis occurs (cytoplasm divides)Two complete identical cells are formedSlide22Slide23
INTERPHASE
Before
a cell divides, its
chromosomes
are copied exactly in INTERPHASE to form two chromatids (“sister” chromosomes). This process is called replication; ATP is synthesised – provides energy for cell division; organelles are replicated and proteins are made, chromosomes condense – becoming shorter and fatter
PROPHASE
Nuclear
envelope breaks down; chromosomes lie freely in cytoplasm; centrioles move to opposite ends of the cell, forming protein (tubulin) fibres across it called a spindle – fibres extend to the equator of the cell
METAPHASE
Chromosomes line up at the equator; the spindle fibres from each pole become attached to the centromere of the chromosomes
ANAPHASE
The spindle fibres contract; the centromeres are split and the pairs of sister chromatids are separated and dragged to opposite poles assuming a “V” shape – the centromeres lead; a complete set of chromosomes is therefore found at each pole; energy (ATP) is required
TELOPHASE
Chromatids reach their respective poles and uncoil – become thin and long again – now called chromosomes again – no longer visible under LM; spindle fibres break down; nuclear envelope forms around each group of chromosomes – forming two nuclei; cytokinesis follows – cytoplasm divides and a plasma membrane forms two form two individual cells; cell enters interphase once again Slide24
Animation
http://www.cellsalive.com/mitosis.htm