pancreatic steatosis with improved reproducibility Shingo Kato 1 Daisuke Utsunomiya 2 Atsushi Nakajima 3 1 Department of Clinical Cancer Genomics Yokohama City University Hospital Yokohama Japan ID: 1047775
Download Presentation The PPT/PDF document "Three-dimensional analysis of pancreatic..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
1. Three-dimensional analysis of pancreatic fat by fat-water magnetic resonance imaging provides detailed characterization of pancreatic steatosis with improved reproducibilityShingo Kato1, Daisuke Utsunomiya2, Atsushi Nakajima3.1. Department of Clinical Cancer Genomics, Yokohama City University Hospital, Yokohama, Japan. 2. Diagnostic Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan3. Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan.
2. Proton Density Fat Fraction（PDFF）Fat Fraction = Water + FatFatx 100%An Tang et al. Radiology 2014 Vol. 274, No. 2
3. PancreasDetection of Pancreatic steatosis by fat-water MRIlow degreehigh degree
4. Pancreatic PDFF calculated from small ROIs varied widely Pancreatic PDFF calculated from small ROIsROIsThe representative result of the evaluation of the variations in values of hepatic or pancreatic PDFF depending on the positions of the ROIs. The values of the pancreatic PDFF measured using small ROIs varied widely depending on the locations of the ROIs.
5. Area #1 (mm2) x PDFF #1 (%) + Area #2 x PDFF #2 + ・・・ + Area #X x PDFF #XArea #1 + Area #2 + ・・・ + Area #XWhole-pancreatic PDFF (%) =Slice #1Slice #2Slice #X・・・Area #1Area #2Area #XThree-dimensional analysis of pancreatic PDFF
6. Inter-observer variability of whole pancreatic PDFFWhole-pancreatic PDFF (%)Sampleinter-observer variability .observer#1#2#3#4#5#6#7
7. Correlation between whole-pancreatic PDFF and the clinical characteristics. p = 0.039 <65>65Age (years old)p = 0.0093<25>25BMI (kg/m2)Diabetesp = 0.0055-+Whole-pancreatic PDFF (%)Whole-pancreatic PDFF (%)Whole-pancreatic PDFF (%)
8. Whole-pancreatic PDFF was not correlated with hepatic and NAS scorep = 0.76, r = 0.025p = 0.29
9. ConclusionWe developed a new measurement method of the pancreatic PDFF with greater reproducibility. Using this method, we characterized pancreatic steatosis in detail. This novel measurement method allows accurate estimation of the severity of pancreatic steatosis and is therefore useful for the detailed characterization of pancreatic steatosis.