with Affine Gap Erin Howell Alternative Splicing Identifying alternative splicing sites with an alignment Look for patterns in gene splicing Use affine gap to identify splice sites Data ATF3 ID: 1006417
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1. Alternative splicing:Sequence Alignment with Affine GapErin Howell
2. Alternative Splicing:Identifying alternative splicing sites with an alignmentLook for patterns in gene splicingUse affine gap to identify splice sitesDataATF3 PCDH15
3. Layout and associated problems:Filling patternBacktracking designWeightingPrioritization
4. Discussion:Alternative alignment varies a lotWhat constitutes a meaningful result?Weighting and organization have a HUGE impact on alignmentFuture: splicing between species?
5. Sources:UCSC Genome Browser search forATF3 (Homo sapiens activating transcription factor 3 (ATF3)PCDH15 (Homo sapiens protocadherin-related 15 (PCDH15)Downes, S. (2004). Alternative splicing, the gene concept, and evolution. History & Philosophy of the Life Sciences, 26(1), 91-104. Retrieved December 15, 2015, from http://0-www.jstor.org.catalog.multcolib.org/stable/23333382