PPT-13 Plasma lipids and lipoproteins

Plasma lipids 200 Lipoproteins 201 Fatty acids 200 Disorders of lipid metabolism 207 Cholesterol 201 Investigation of hyperlipidaemias 214 FATTY ACIDS Lipids play a critical role in almost all aspects of . Lipids are….. It can be defined as . nonpolar. organic compound insoluble in polar solvent , but . soluble in organic solvents. such as benzene ,ether, . chloroform.. Biological role of lipids. :. Lipids are relatively insoluble in water.. They are soluble in . nonpolar. solvents such as chloroform , diethyl ether, acetone, benzene and ether.. The hydrophobic (water hating) nature of lipids is due to the predominance of hydrocarbon chain.(-CH2-CH2-CH2-) in their structure. Dr. Huda Hania. Lipid chemistry . Lipid chemistry . Definition . Fats and Oils (triglyceride) . Waxes. Steroids. Fat- soluble vitamins. Phospholipid. Mono- di glycerides . Lipid compounds including: . Learning Objectives. Learn what a triglyceride is.. Learn what a fatty acid is.. Learn the structure of a . phospholipid. .. Learn how lipids are tested for.. What is a lipid?. Like most other biochemical substances, lipids contain . Pratt & . Cornely. , . Ch. 8. Lipids and Membranes. There is a lot of important biochemistry of lipids.. We won’t cover it all!. The key points for this class have to do with their role in membranes and fat . nonpolar. organic compound insoluble in polar solvent , but . soluble in organic solvents. such as benzene ,ether, chloroform.. Biological role of lipids. :. Lipids are found naturally in all living organisms.. Lipoproteins. are . types of . Compound Lipids /. Conjugated . Proteins. .. Lipoproteins . are . macromolecules. formed by aggregation of. . :. Lipids . (Neutral . and A. mphipathic ). Proteins. ( Apoprotein) in the human body.. PSC 3110 – Fall semester 2008. Introduction. Definition: water insoluble compounds. Most lipids are fatty acids or ester of fatty acid. They are soluble in non-polar solvents such as petroleum ether, benzene, chloroform. Glycrophospholipids degradation . Lipoproteins. G. L. Y. C. E. R. O. L. FATTY ACID. FATTY ACID. PHOSPHOACYLGLYCEROL. PHOSPHATE. ALCOHOL. Again this is the representation structure of glycerophospholipids.. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . CVS. 2018/2. ND. SEMESTER. • Four major groups of lipoproteins are recognized: Chylomicrons transport lipids resulting from digestion Lipid Metabolism and . absorption.Derived. from intestinal absorption of TG . . . very importance to . medical practice owing to its strong relations to . Arteriosclerosis and thus obesity, HTN, DM and . other abnormalities . . Good prognosis in the . manegment. of these conditions are . Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 15. What are lipids?. Lipids are heterogeneous, hydrophobic, compartmentalized in membranes, as droplets of triacylglycerol (TAG), or in lipoprotein (LP) particles or, or protein-bound. . are a large and diverse group of naturally occurring organic compounds that share some general . properties. .. General Properties of Lipids. Insoluble . in water.. Soluble in non-polar organic solvents .