Table showing the Differences between Hepatitis A B C D and E Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E Aetiology cause Hepatitis A Virus Hepatitis B Virus Hepatitis C Virus ID: 927453
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Slide1
PG Lecture
17.07.2020
Slide2Viruses of Hepatitis
Slide3Table showing the Differences between Hepatitis A, B, C, D and E
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
Aetiology (cause)
Hepatitis A Virus
Hepatitis B Virus
Hepatitis C Virus
Hepatitis D Virus
Hepatitis E Virus
Structure
Single stranded RNA virus
Single Stranded DNA virus
Single Stranded RNA virus
Single Stranded RNA virus
Single Stranded RNA virus
Presence of Envelope
Non-enveloped virus
Enveloped virus
Enveloped virus
Enveloped virus
Non-enveloped virus
Viral Family
Picorna
virus
Hepadna
virus
Flavi
virus
No Viral Family but known as Delta virus
Hepevirus
Incubation Period
2 to 7 weeks
6 weeks to 6 months
2 to 23 weeks
2 to 8 weeks
3 to 9 weeks
Slide4Table showing the Differences between Hepatitis A, B, C, D and E
Mode of Transmission
Eating contaminated food and drinks (
Feco
-oral spread)
Mostly by blood and sexual contact
By blood and sexual contact
Coinfection
or
superinfection
with Hepatitis B
Feco
-orally spread
Mother to Child
May not be transmitted to baby in pregnancy
Mother can transmit to baby during birth
Mother can transmit to baby during birth
May not be transmitted to baby in pregnancy
May not be transmitted to baby in pregnancy
Treatment and Drugs
No drugs; only treated by supporting the body to fight the infection
Antiretroviral drugs (e.g.
Lamivudine
)
Harvoni
(
ledipasvir
and
Sofosbuvir
) and
Sovaldi
(only
sofosbuvir
)drugs
Lonafarnib
and
pegylated
interferon
No treatment, only supportive management
Severity and Complications
Does not cause Liver cancer
Can cause Liver cancer
Can cause Liver cancer
Does not cause Liver cancer on its own but worsen it in Hepatitis B infection
Does not cause liver cancer. It has bad outcome in Pregnant women
Vaccines availability
There is a vaccine
There is vaccine available
There is no vaccine
Vaccination against Hepatitis B is protective
There is vaccine
Slide5Differences between Hepatitis A, B, C, D and E
Hepatitis
B and C can cause liver disease such as liver cirrhosis and liver cancer but Hepatitis A and E does not
Hepatitis E affects pregnant women more
Hepatitis B is more deadly than hepatitis C as
Hep
B is more infectious and drugs of treatment do not cure the disease but reduces the rate of progression.
Hepatitis A, B and E have vaccines whereas Hepatitis C and D have none
Drugs for treatment of Hepatitis B and C are available whereas Hepatitis A and E treatment are supportive
In terms of Epidemics, Hepatitis A causes outbreaks more than other kinds of Hepatitis
The viral infection with the shortest incubation occurs in Hepatitis A and D whereas the longest incubation period is with Hepatitis B and C
The commonest form is Hepatitis A whereas D is rare and only occurs in those with
Hep
B
Hepatitis C is curable but the drugs are more costly than any other type of Hepatitis
The Only DNA virus is Hepatitis B
Slide6Comparison (similarities) of Hepatitis A, B, C, D and E viruses
All
are caused by Viruses named according to the letters of the alphabets
All forms of viral
hepatitides
have similar symptoms such as vomiting, yellowish eyes and skin (Jaundice), fatigue ( feeling tired), abdominal pains
They affect the liver cells
Hepatitis B and C both can cause liver cirrhosis or liver cancer
All types have acute stages
Hepatitis B, C and D have envelops
Hepatitis A and E have no envelop
Hepatitis A, B and C have viral families
Hepatitis D have no family while Hepatitis E virus family may be controversial
Hepatitis A and E are both transmitted
feco
-orally
Hepatitis B and C have both have similar methods of spread by blood and contact with body fluids such as during sexual contact
All are single stranded viruses
With the exception of Hepatitis B being a DNA virus, other kinds such as Hepatitis A, C, D and E are RNA viruses
Slide7THANKS