Jacqueline Villalobos, ND - PowerPoint Presentation

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Jacqueline Villalobos, ND

Doctor of Naturopathic MedicineAcademy for Teachers of Young Children July 16, 2020

Optimizing behavior and health of atypical children with diet

and

lifestyle

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Physical and mental balance are affected by the quality of the food we eat.

http://www.health.harvard.edu/blog/nutritional-psychiatry-your-brain-on-food-201511168626

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IMPACT OF IMPAIRED INTESTINAL PERMEABILITY Intestinal problemsMalabsorbtionBloatingGasStomachache

ConstipationDiarrheaIntestinal inflammationDysbiosis

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CAUSES OF IMPAIRED INTESTINAL PERMEABILITY GLUTENIn genetically susceptible people, gluten increase the production of zonulin which is associated with impaired intestinal permeability

FOOD SENSITIVITIESDairy, soy, corn, egg & peanut are among the most common foods that trigger sensitivities HIGHLY REFINED FOODS AND FOOD-LIKE SUBSTANCESPreservatives, colorings, flavorings, thickeners, flavor enhancers, fast food, hydrogenated oils

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IMPACT OF IMPAIRED INTESTINAL PERMEABILITY Dysbiosis or unbalanced intestinal bacteria DepressionAnxietyPessimism

Impaired social functionMental fogginessInflammation

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Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic SubjectsAuthor links open overlay panelErmanEsnafogluMD1SelmaCırrıkPhD2

Sema NurAyyıldızMD3AbdullahErdilMD4Emine YurdakulErtürkMD4AbdullahDaglıMD4TevfikNoyanMD3

Objective

To evaluate the serum levels of zonulin, which regulates tight junctions between

enterocytes

and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (

ASDs

).

Study design

Serum

zonulin

levels were determined in 32 patients with

ASD

and 33 healthy controls using an enzyme-linked

immunosorbent

assay. The severity of

ASD

symptoms was assessed with the Childhood Autism Rating Scale.

Results

Serum

zonulin

levels were significantly higher in the patients with

ASD

(122.3 ± 98.46 

ng

/

mL

) compared with the healthy controls (41.89 ± 45.83 

ng

/

mL

). There was a positive correlation between

zonulin

levels and Childhood Autism Rating Scale score when all subjects were assessed (r = 0.523; 

P

 < .001).

Conclusions

This study suggests that

zonulin

, which regulates intestinal permeability, plays a role in the development of symptoms of

ASD

.

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ReinoculateSupport the formation of healthy gut bugs with prebiotic foodsHigh quality organic yogurtGarlic, onion, leeksBarley, flax, oats

Artichokes, sauerkrautMiso, tempehSupplement high quality probiotics

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The role of probiotics in children with autism spectrum disorder: A prospective, open-label studySanaa Y. ShaabanPediatric Department, Faculty of Medicine, Ain

Shams University, Cairo, Egypt,Yasmin G. El Gendy,Nayra S. Mehanna,Waled M. El-

Senousy,Howaida S. A. El-

Feki

Methods:

 Gastrointestinal (GI) flora were assessed by quantitative real-time

PCR

of stool samples of 30 autistic children from 5 to 9 years old. GI symptoms of autistic children were assessed with a modified six-item Gastrointestinal Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with Autism Treatment Evaluation Checklist (

ATEC

) before and after 3 months of supplementation of

probiotics

nutritional supplement formula (each gram contains 100 × 10

6

 colony forming units of three

probiotic

strains; 

Lactobacillus acidophilus

, 

Lactobacillus

rhamnosus

 and 

Bifidobacteria

longum

).

Results:

 After

probiotic

supplementation, the stool

PCR

of autistic children showed increases in the colony counts of 

Bifidobacteria

 and 

Lactobacilli

 levels, with a significant reduction in their body weight as well as significant improvements in the severity of autism (assessed by the

ATEC

), and gastrointestinal symptoms (assessed by the 6-GSI) compared to the baseline evaluated at the start of the study.

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REMOVE FOOD TRIGGERS Test for food sensitivities , dairy & gluten are common sensitivitiesEat grass fed, organic, hormone- free meats

If dairy is not a problem, eat or drink only organic, hormone free dairy Avoid artificial sweeteners, colorings, preservatives, flavorings, MSGMonosodium glutamate neurotoxicity increases beta amyloid in the rat hippocampus: A potential role for cyclic AMP protein kinase

http://www.sciencedirect.com/science/article/pii/S0161813X1400062XAnn

Nutr Metab 2016;68(suppl 1):43–50 Truths, Myths and Needs of Special Diets: Attention-Deficit/Hyperactivity Disorder, Autism, Non-Celiac Gluten Sensitivity, and Vegetarianism by Sylvia

Cruchet

et al.

https://www.karger.com/Article/PDF/445393

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RemoveEliminate known food sensitivities ie. Dairy, gluten, eggs, soy, cornEliminate drugs that harm the gut such as NSAIDS ibuprofen, celebrex

, endomethacinTreat bacterial or yeast overgrowthAvoid food additives, preservatives, flavorings, colorings, pesticidesAvoid refined and prepared foods

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Consider offering healthier snacksFresh fruitRaisins Rice crackersGluten free cheeriosRaw carrot sticksRaw sunflower or pumpkin seedsHealthier “trail mix”: cheerios, raisins and sunflower seeds

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Eat foods that existed 200 years agoThe Mediterranean dietIncreased use of fruits and vegetables daily: ‘5-9 a day’ is a reasonable minimum (excellent source of dietary fiber.)Eat whole, unrefined grains, legumes/beans, raw seeds & nuts (Fiber)

Extra-virgin olive oil, coconut oil, or non-GMO Canola oil in preference to other oils and fats. Limit portion of wild game or grass fed beef to 3 ouncesWild caught fish and seafood

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Organic fruits and vegetables :Provide life force, QiFeed the microbiomeIncrease dietary fiberIncrease satietyProvide digestive enzymes

Rich in vitamins and mineralsProvide plant medicine5 -9 servings a day

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Whole, unrefined grains and legumesFeed the microbiomeIncrease dietary fiberIncrease satietyRich in vitamins and mineralsProvide plant medicineSmall servings ½ cup

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Raw seeds and nutsHigh in anti-inflammatory fatsProvide high fiberProvide vitamins and mineralsIncrease satietyEat small servings daily, ¼ cup

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Highest quality organic oilsExtra Virgin Olive oilCoconut oilNon-GMO Canola oilAvocado oilButterGrape seed oil*

Sesame oil*Flax seed oil* *do not heat

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Small serving (3 oz.) of animal productsWild caught cold water fishGrass fed organic beefWild gameOrganic chickenOrganic dairyOrganic eggs

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CIRCADIAN RHYTHMSOften referred to as the "body clock", the circadian rhythm is a cycle that tells our bodies when to sleep, rise, eat--regulating many physiological processes. This internal body clock is affected by environmental cues, like sunlight and temperature.

https://www.psychologytoday.com/basics/circadian-rhythm

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Timing is importantEntrain optimal digestion by eating around the same time every dayEat 3 meals a day, starting with breakfast Prioritize mealtime, encourage mindful eatingInvest 15-30 minutes 3 times a day for relaxing, eating and digesting

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J Am Acad Child Adolesc Psychiatry. 2020 Jan 23;S0890-8567(20)30034-4. doi: 10.1016/j.jaac.2019.12.007. Online ahead of print.

Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum DisorderBeth A Malow 1, Robert L Findling 2, Carmen M Schroder

 3, 

Athanasios Maras 4, 

John

Breddy

 

5

, 

Tali

Nir

 

6

, 

Nava

Zisapel

 

6

, 

Paul

Gringras

 

7

Affiliations expand

PMID

: 31982581

 

DOI

: 

10.1016/j.jaac.2019.12.007

Free article

Abstract

Objective: 

A recent 3-month double-blind, placebo-controlled study demonstrated efficacy and safety of pediatric prolonged-release melatonin (

PedPRM

) for insomnia in children with autism spectrum disorder. This study examined the long-term effects of

PedPRM

treatment on sleep, growth, body mass index, and pubertal development.

Method: 

Eighty children and adolescents (2-17.5 years of age; 96% with autism spectrum disorder) who completed the double-blind, placebo-controlled trial were given 2 mg, 5 mg, or 10 mg

PedPRM

nightly up to 104 weeks, followed by a 2-week placebo period to assess withdrawal effects.

Results: 

Improvements in child sleep disturbance and caregiver satisfaction with child sleep patterns, quality of sleep, and quality of life were maintained throughout the 104-week treatment period (p < .001 versus baseline for all). During the 2-week withdrawal placebo period, measures declined compared with the treatment period but were still improved compared with baseline.

PedPRM

was generally safe; the most frequent treatment-related adverse events were fatigue (6.3%), somnolence (6.3%), and mood swings (4.2%). Changes in mean weight, height, body mass index, and pubertal status (Tanner staging done by a physician) were within normal ranges for age with no evidence of delay in body mass index or pubertal development.

Conclusion: 

Nightly

PedPRM

at optimal dose (2, 5, or 10 mg nightly) is safe and effective for long-term treatment in children and adolescents with autism spectrum disorder and insomnia. There were no observed detrimental effects on children's growth and pubertal development and no withdrawal or safety issues related to the use or discontinuation of the drug.

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Daily physical activity enhances sleepExercise in the morning raises your basal metabolic rate, so that you burn more calories in your resting state.A walk outdoors in the early morning light increases your energy level and serenity for the rest of the day.Avoid vigorous exercise for 4 hours prior to bedtime as it increases your body temperature, cortisol levels, and alertness, which can interfere with your ability to fall asleep.

A gentle, relaxing walk at dusk helps your SCN receive the message that night is falling and promotes the secretion of Melatonin.

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Am J Psychiatry. 2020 Jun 1;177(6):518-525. doi: 10.1176/appi.ajp.2019.19060666. Epub 2020 May 7.

Sleep Onset Problems and Subcortical Development in Infants Later Diagnosed With Autism Spectrum DisorderKatherine E MacDuffie 1, Mark D Shen 1, 

Stephen R Dager 1

, Martin A Styner 1

, 

Sun

Hyung

Kim

 

1

, 

Sarah Paterson

 

1

, 

Juhi

Pandey

 

1

, 

Tanya St John

 

1

, 

Jed T

Elison

 

1

, 

Jason J Wolff

 

1

, 

Meghan R Swanson

 

1

, 

Kelly N

Botteron

 

1

, 

Lonnie

Zwaigenbaum

 

1

, 

Joseph

Piven

 

1

, 

Annette M Estes

 

1

Affiliations expand

PMID

: 32375538

 

DOI

: 

10.1176/appi.ajp.2019.19060666

Abstract

Objective: 

Sleep patterns in children with autism spectrum disorder (

ASD

) appear to diverge from typical development in the second or third year of life. Little is known, however, about the occurrence of sleep problems in infants who later develop

ASD

and possible effects on early brain development. In a longitudinal

neuroimaging

study of infants at familial high or low risk for

ASD

, parent-reported sleep onset problems were examined in relation to

subcortical

brain volumes in the first 2 years of life.

Methods: 

A total of 432 infants were included across three study groups: infants at high risk who developed

ASD

(N=71), infants at high risk who did not develop

ASD

(N=234), and infants at low risk (N=127). Sleep onset problem scores (derived from an infant temperament measure) were evaluated in relation to longitudinal high-resolution T

1

 and T

2

 structural imaging data acquired at 6, 12, and 24 months of age.

Results: 

Sleep onset problems were more common at 6-12 months among infants who later developed

ASD

. Infant sleep onset problems were related to

hippocampal

volume trajectories from 6 to 24 months only for infants at high risk who developed

ASD

. Brain-sleep relationships were specific to the hippocampus; no significant relationships were found with volume trajectories of other

subcortical

structures examined (the

amygdala

, caudate,

globus

pallidus

,

putamen

, and thalamus).

Conclusions: 

These findings provide initial evidence that sleep onset problems in the first year of life precede

ASD

diagnosis and are associated with altered

neurodevelopmental

trajectories in infants at high familial risk who go on to develop

ASD

. If replicated, these findings could provide new insights into a potential role of sleep difficulties in the development of

ASD

.

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RebalanceMake a commitment to maintaining healthier lifestyle habitsPrioritize sleepWe all need daily exerciseManage stress with exercise & a routineSlow down, especially during mealtimeEat a primarily plant based diet, foods that existed 200 years ago, most of the time.

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Steps to successParents who model the new behavior help children to be more successful

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Connect the new behavior to a positive emotion

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Congratulate every success

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THIS IS A LIFELONG JOURNEY

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Contact Information:Jacqueline Villalobos, ND330 N Campo St.Las Cruces, NM 88001971-409-0603

jacquiv.jv@gmail.comwww.jacquelinevillalobosnd.com