NC State University at the NC Research Campus Mission Statement Leading the discovery and delivery of innovative plantbased solutions to advance human health NC Research Campus Academic Partners ID: 933511
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Slide1
Plants for Human Health InstituteNC State University at the NC Research Campus
Mission Statement
Leading the discovery and delivery of innovative plant-based solutions to advance human health
Slide2NC Research Campus
Academic Partners
David H. Murdock Research Institute
Corporate Partners
Academic Partners
North
Carolina State
University
Plants for Human Health Institute
UNC Chapel Hill Nutrition Research InstituteUNC CharlotteBioinformatics Services DivisionUNC GreensboroCenter for Translational Biomedical ResearchDuke UniversityClinical and Translational Science InstituteNorth Carolina Central University Nutrition Research ProgramNorth Carolina A&T State UniversityCenter for Excellence in Post-Harvest TechnologiesAppalachian State UniversityHuman Performance LaboratoryRowan Cabarrus Community CollegeBiotechnology Training Center
Corporate Partners
LabCorp
Dole
General Mills
EnDev
Laboratories
Sensory Spectrum
Cabarrus Health Alliance
Carolinas Health Care System
Slide3DISCOVERY
Improving
the nutritive and
bioactive properties
of plant foods (focus on fruits and
vegetables
), using a portfolio of
strategies
from classical breeding to systems biology.
Slide4NC Research CampusDELIVERY: Extension Specialists dedicated to the dissemination of PHHI research
Program creation and materials to support community and statewide health initiatives.
Direct collaboration with PHHI Research Faculty and other NCRC onsite partner institutes to enhance the reach of program awareness and consumer knowledge.
Focusing on Public Health, K-
12 STEM Education, Horticultural
Entrepreneurship and Business Development.
Slide5PHHI Budget Growth
*
Supported collaborative
projects with main
campus faculty in research areas of interest
Slide6Supporting CALS Five Core Strategic Themes
Enhancing the production, quality, accessibility and profitability of food, plant, animal and bioenergy products for North Carolina, the nation and the world;
Ensuring environmental stewardship and sustainability of air, land, soil and water resources;
Creating a food supply that is safe, secure, healthy, affordable and of high quality;
Improving human health and well-being for individuals, families and communities; and
Preparing students and stakeholders for leadership and success in the global workforce.
Slide7Horticultural Science
Plant and Microbial Biology
Food Bioprocessing and
Nutrition Sciences
Plant Pathology
Animal Science
Biological Sciences
Molecular and Structural Biology
Cooperative Extension
Seed Grant Initiatives & Collaborations
Functional genomics and functional
phenotyping
of blueberry fruits
Bitter-tasting prebiotics for gastrointestinal and metabolic health
Development and analysis of hypoallergenic polyphenol-edible protein matrices using translational models
“
Hopportunity
”: Metabolite and transcriptional
profiling
to identify regulation of specialized metabolism in
hop
(
Humulus
Iupulus
)
Black Raspberry: Investigating a unique N.C. fruit from genomics to human health
Slide8Industry Collaboration
10 PhD
Students
101
undergraduate interns from 17 colleges and universities since 2013
The Plant Pathways Elucidation Project (P
2
EP)
is a dynamic $3.5 million program that engages college students from across North Carolina in a first-of-its-kind education & research endeavor.
Program Goals
Educational opportunity
Scientific discovery
Knowledge base creation
Based at the N.C. Research Campus in Kannapolis
Mapping plant pathways for blueberries, broccoli, oats, strawberries, bananas and pineapple.
Slide9Food, Bioprocessing and Nutrition Sciences DR. SLAVKO KOMARNYTSKY – PHARMACOGENOMICS (FY12)
Role of diet and nutrition in prevention of metabolic diseases and inflammation
When treated with natural anti-inflammatory
diterpenoid
(
triptolide
), diet induced obese mice do not develop diabetes.
Natural steroids present in green leafy vegetables like spinach and cabbage promote muscle health.
DR. MARY ANN LILA – PHYTOCHEMISTRY (FY09)
Biologically-active compounds stably captured in shelf stable versatile food matrices. Biofortified phytochemically-enriched food ingredients prepared from fruit source (i.e. Kale, Muscadine)Phytochemical characterization of wild Alaskan blueberries and cranberries.Testing anti-inflammatory activity of Alaskan berry extracts and enriched fractions.
Slide10Food, Bioprocessing and Nutrition Sciences DR. MARIO FERRUZZI, TRANSLATIONAL NUTRITION (FY17)
Exploring
the role of the food matrix in delivery of micronutrients and phytochemicals
.
Discovering the interactions between plant phytochemicals and macro-nutrients (proteins and carbohydrates) and their impact to product quality and health promoting properties in humans.
Developing insights into the role these interactions play in modifying nutrient availability, gut microbial communities and markers of disease.
DR. COLIN KAY, TRANSLATIONAL NUTRITION (FY16)
Identifying
metabolites of berry consumption as biomarkers of intake and active compounds for the prevention of disease.
Nutritional biochemistry and human vascular interventions and controlled dietary feeding trials.Utilizes human and cell-based studies to investigate the effects of diet on disease.
Slide11Plant Microbial and Biological Sciences
DR. XU
“
SIRIUS
”
LI - PLANT METABOLIC PATHWAY ENGINEERING (FY12)
Harnessing natural variation in plant secondary metabolism for gene and pathway
discovery.
Model
plant Arabidopsis can be translated to the closely related vegetables such as broccoli and cabbage.DR. TZUNG FU HSIEH – SYSTEM BIOLOGY (FY13)Genomic and epigenetic approaches to elucidate regulation of key plant developmental and metabolic pathways.Epigenetic regulation of genomic imprinting.Active DNA demethylation in plant reproduction.Tissue/cell type specific transcriptome and
methylome
.
Transgenerational
epigenetic inheritance.
Genomic-assisted gene discovery in important crop species.
Slide12Horticultural ScienceDR. PENELOPE PERKINS-VEAZIE, POSTHARVEST PHYSIOLOGY (FY09)
Release of New Blackberry
“
VON
”
based on High Quality and shelf
life
Testing Mango and Watermelon (as Freeze Dried Powders) for altered glucose metabolism and slowed osteoporosis in Clinical Trials Testing of NC Watermelons for
Citrulline content (Vasodilator) and improved shelf life from grafting
DR. MASSIMO IORIZZO, BERRY GENOMICS (FY15)Focusing on plant breeding and genomics to improve nutritional value of small fruit and vegetablesUnderstanding the genetic mechanisms controlling the accumulation and diversification of health promoting phytochemicals in small fruits and vegetablesGoals to establish cost effective breeding and genomics strategies to develop new varieties or natural products with improved nutritional value.
Slide13Animal ScienceDR. DEBORA ESPOSITO, REGENERATIVE MEDICINE (FY17)Inflammation and tissue regeneration as it applies to wound healing and skin care
Cell
-based biological screening in conventional, 3D matrices, and stem culture technologies
Muscle aging and repair
DR. GIUSEPPE VALACCHI, REGENERATIVE MEDICINE (FY17)
Evaluating
the effect of exogenous and endogenous sources of oxidative stress on target organs
Identifying signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing
Discovering how new topical approaches (derived from natural compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological
situations