Treatment of plasmacytoid dendritic cells with CpG DNA leads to the production of inflammatory cytokines like interferon alpha IFN α IFN α increases the expression of maturation markers on MDSCs allowing them to mature and lose immunosuppressive function ID: 935746
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Slide1
IFN
α Induces MDSC Maturation and Loss of Suppressive Function
®
Treatment of plasmacytoid dendritic cells with CpG DNA leads to the production of inflammatory cytokines like interferon alpha (IFN-
α
). IFN-α increases the expression of maturation markers on MDSCs, allowing them to mature and lose immunosuppressive function. Adapted from: Zoglmeier, C. et al. 2011. Clin. Cancer. Res. 17:1765.
Tumor Promotion
CpG DNA
TLR9
IFN
α
Dendritic Cell
Macrophage
MDSC
Plasmacytoid Dendritic Cell
Maturation
Sca1
Ly6C
F4/80
Endosome