PPT-NS5A and polymerase inhibitors

Mark Sulkowski MD Professor of Medicine Johns Hopkins University Baltimore Maryland 21212 Case 57 yo woman with genotype 1a and bridging fibrosis PROVE1 study treated with TVR x 12 . Mark Sulkowski, MD. Associate Professor of Medicine . Johns Hopkins University School of Medicine . Limitations of PegIFN + Ribavirin . (with or without protease inhibitors). Antiviral activity is host + virus genotype dependent . Matthew Luu, Yuan Fang (Pearl) Cai, Shiming Sun, . Ziyi Cheng. PHM142 Fall . 2016. Coordinator. : Dr. Jeffrey Henderson. Instructor: Dr. David Hampson. What is Hepatitis C? . Flaviviridae. virus family. Nahla . Bakhamis. Multiple copies of specific DNA . sequences;. . ‘Molecular Photocopying’ . Polymerase Chain Reaction. 1983;. In . vitro. enzymatic amplification of specific DNA sequences from . Inhibitors. anodic inhibitors. : . p. hosphates. s. ilicate . c. ompounds. . Cathodic inhibitors. poly-p. hosphates. . Ca(HCO3)2. methylamino-phosphate. (c). . mixed anodic and cathodic inhibitors. CHM . 341. Suroviec. . Fall . 2016. I. . Nucleotides, Nucleic Acids and Bases. Bases. Planar, aromatic, heterocyclic. Purine (2 rings). Pyrimidine (1 ring) . Adenine (A). Guanine (G). Thyamine (T). Jason Lee. Treatment. Early detection of mutation carriers, followed by frequent . colonospic. . polypectomy. Management of symptoms resembling Lynch Syndrome or MAP; including prophylactic . colononectomy. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States, and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.. (MK-1439; DOR). . NNRTI. Merck. Filed with USFDA. Cabotegravir-LA. (GSK-744; CAB). For . PrEP. INI. ViiV. Topical microbicide. Oral. Long-acting (LA) parenteral. 1. Fostemsavir. (BMS-663068). Prodrug of . CHM . 341. Suroviec. . Fall . 2016. I. . Nucleotides, Nucleic Acids and Bases. Bases. Planar, aromatic, heterocyclic. Purine (2 rings). Pyrimidine (1 ring) . Adenine (A). Guanine (G). Thyamine (T). 322 BCH. Exp. (8). In this experiment, we will continue to study . acid phosphatase . kinetics.. Objectives. To . study the effect of inhibitors on the rate of an enzymatic reaction.. To . determine the type of inhibition of acid phosphatase by inorganic phosphate and sodium fluoride. . in molecular biology . DNA REPLICATION . DNA replication.  . …. It is . the process of producing two identical copies from one original DNA molecule. This biological process occurs in all living . DEPARTMENT OF MICROBIOLOGY. CLASS -TYBSC. SUBJECT- Genetics and Molecular Biology -I. Lecture-TRANSCRIPTION . RNA . polymerase. Core polymerase . +2 +3 +4 . -4 -3 -2 -1 . -70 to +30. Technique Dr R. K. Pandey 1) In most organisms, DNA is a genetic material which stores the information template for the synthesis of RNA and subsequently protein. Name the processes a, b, c represen ا . د . جمال احمد عبد الباري. Chromosomes . :. Are DNA- protein complex or nucleoprotein the information transmitted by the genes from one cells to another is stored in the DNA, or in the specific base sequences of DNA macromolecules..