petercelecgmailcom wwwimbmsk Stem cells Totipotency All tissue types Pluripotency All tissues except placenta and amniotic sac Multipotency Several related ID: 935838
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Slide1
Embryology
Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPHpetercelec@gmail.comwww.imbm.sk
Slide2Stem cells
TotipotencyAll
tissue
typesPluripotencyAll tissues except placentaand amniotic sacMultipotencySeveral related tissue types
Slide3Slide4Slide5Differentiation
Slide6Programming and reprogramming
Slide7Nucleus transfer
John Bertrand Gurdon (1933 - )
Nobel
prize in Physiology or medicine 2012
Slide8Somatic cell
nuclear transferDolly
(5 July 1996 – 14 February 2003)
Slide9Cloning
Reproductive Therapeutic
Slide10Cloning
Slide11Pluripotency
Slide12iPSC
Shinya Yamanaka
Kyoto University
Slide13Slide14iPS
Reprogramming of differentiated
cells
PluripotencyNo immune responseWithout retroviral vectorsWithout oncogenespH?
Reproducibility
Slide15Shinya
Yamanaka
(1962 – )
Nobel
prize
2012 –
Physiology
or
medicine
Slide16Slide17Malignant transformation
Robert Weinberg (1942 - )Oncogenes
Ras
Tumor
suppressorsRb1
Slide18Hallmarks of cancer
Hanahan
&
Weinberg, Cell, 2000
Slide19Hallmarks of cancer
Hanahan
&
Weinberg, Cell, 2011
Slide20Slide21Malignant transformation
Bert Vogelstein (1949- )
Vogelgram
Slide22Slide23Genometastasis
Slide24Genometastasis
Slide25www.imbm.sk
petercelec@gmail.com