Pathological

Pathological Pathological - Start

2017-07-24 40K 40 0 0

Pathological - Description

events maybe generated by certain transmitter(s).. Somorjai Dávid. N. eurotransmitters. Neurotransmitters are endogenous bioactive substances . Substances used as neurotransmitters belong to three. distinct families:. ID: 572527 Download Presentation

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Pathological




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Presentations text content in Pathological

Slide1

Pathological events maybe generated by certain transmitter(s).

Somorjai Dávid

Slide2

Neurotransmitters

Neurotransmitters are endogenous bioactive substances

Substances used as neurotransmitters belong to three

distinct families:

(1) amines, (2) purines and (3) peptides

Criteria

of chemical neurotransmitters:

1. The synthesis of the chemical transmitter takes place in the

presynaptic neuron

2. The synthesized transmitter or it precursor is stored in the release

compartment of the cell, most frequently in axon terminals

3. Release of the neurotransmitter into the synaptic cleft upon

excitation of the presynaptic element

4. Binding of the transmitter to its receptor/s/ that belong to ionotropic

and metabotropic classes

5. Termination of the action of transmitters and its triggered

mechanisms

Slide3

Glutamate

 powerful excitatory neurotransmittermore than half of the synapsis are glutamate in the CNSplays an important role in learning and memory, plasticity, long term potentiation, neurotoxicitySynthesized by two major pathways:->from α-ketoglutarate and donor amino acids by means of transmission->glutamine by the action of the enzyme glutaminaseThere are at least five excitatory aminoacid repetors ->NMDA is the most importantNMDA is implicated in memory, development and epilepsy

Slide4

Glutamate toxicity

Excitotoxicity = excitatory + toxicity

damaging

t

he

nerve cells and the

brain

-> two general ways

too much glutamate around ->overtoxication of the receiving nerve cell

the receptors for the glutamate can be

oversensitive

Cells become overexcited -> cell damage and/or

death

acute and chronic glutamate

toxicity

the

susceptibility of neurons to excitotoxicity can change tremendously with age

Slide5

Excitotoxicity Theory

Slide6

Thank you for your attention!

Sources:http://web.stanford.edu/group/hopes/cgi-bin/hopes_test/about-glutamate-toxicity/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679930/http://neurotransporter.org/glutamate.html+ seminarium handouts and slides


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