Day 2 Introduction to Pedigree Genetics Week 12 Rincon High School Go Rangers Objectives The Student will be able to 1 Finish the 2 trait P unnet square practice problems 2 Sketch and describe the basic anatomy of a family pedigree ID: 259781
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Slide1
We Are Family! Day 2Introduction to Pedigree Genetics
Week 12
Rincon High School
Go Rangers!Slide2
ObjectivesThe Student will be able to:1.) Finish the 2 trait Punnet square practice problems.
2.) Sketch and describe the basic anatomy of a family pedigree.
3.) Use the information from a pedigree to infer genotypes and answer application questions. Slide3
Different Modes of Inheritance: 3.) X-Linked Recessive
The sex of an individual has been linked to certain disorders, we’ll finish by examining these pedigrees.
New Nomenclature
X
A
= normal
X
a
= the trait (a genetic disease or abnormality) Y = Y chromosome (males only
)
Examples for a Female:
X
A
X
a
, X
A
X
A
,
X
a
X
a
What would the male sex genotype look like?
Examples for Males
: X
A
Y, X
a
Y
New Term: Males are consider “
Hemizygous
,” for their sex chromosomes. Hemi meaning half. Slide4
Let’s Practice
Assign the genotypes (Use X and Y’s now).
Is it possible that the pedigree above is for an X-linked recessive trait?Slide5
Keep Going, almost there!
Assign the genotypes (Use X and Y’s now).
Is it possible that
these pedigrees represent
an X-linked recessive trait?Slide6
Different Modes of Inheritance: 3.) X-Linked Dominant
X
A
=
the trait (a genetic disease or abnormality)
X
a
= Normal Y = Y chromosome (males only)
Common X-Linked Dominant Diseases: Few and Rare
!
V
itamin
D resistant rickets
Rett's
syndrome
Fragile X syndromeSlide7
Getting the hang of this yet? Let’s see!Slide8
Our First Genetic Case Study!When Queen Victoria of England was seventeen, she met one of her many cousins, Prince Albert of Saxe-Coburg. She fell deeply in love with him, and several years later, when they were both twenty years old, Victoria proposed to Albert.
They were married on February 11, 1840; both were deliriously happy, and Victoria made Albert Prince Consort, giving him an equal say in the running of the country. What neither of them knew at the time was that Victoria was carrying the gene for hemophilia.Slide9
Your Mission!You are a genetic detective tasked with figuring out what type of inheritance pattern this disease is following in Queen Victoria’s family pedigree.
You’ve conducted your preliminary research and constructed a rough pedigree of the family history. You’ve also concluded that the disease is not autosomal.
Help us Obi Wan Kenobi you’re our only hope!....I know Ms. G, 5 bucks. Slide10Slide11
Don’t forget Homework due tomorrow!
1.) Family
Pedigree’s Due
2.) Punnett
Square challenge problem due (Optional)