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Botulinum toxin injections for low-back pain and sciatica Botulinum toxin injections for low-back pain and sciatica

Botulinum toxin injections for low-back pain and sciatica - PowerPoint Presentation

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Uploaded On 2022-06-01

Botulinum toxin injections for low-back pain and sciatica - PPT Presentation

Waseem et al 2011 This document is licensed under a Creative Commons Attribution NonCommercialNoDerivatives 40 International License httpcreativecommonsorglicensesbyncnd40 ID: 913004

injections pain toxin botulinum pain injections botulinum toxin term long evidence injection effective short contents function waseem 2011 iwh

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Slide1

Botulinum toxin injections for low-back pain and sciatica

Waseem et al (2011)

This document is licensed under a Creative Commons Attribution NonCommercialNoDerivatives 4.0 International License: http://creativecommons.org/licenses/by-nc-nd/4.0/ That means this document can be used and shared as long as IWH is credited as the source, the contents are not modified, and the contents are used for non-commercial purposes. If you wish to modify and/or use the contents for commercial purposes, please contact ip@iwh.on.ca.

Slide2

Botulinum toxin injections for low back pain

Waseem et al (2011)Overview of the study

Objectives To determine the effects of botulinum toxin injections in adults with low back pain (LBP)Methods Evidence current up to 1 February 2010 Participants: Adults (18 and older) with non-specific LBP and/or sciatica (acute, subacute, or chronic)

Interventions: All intramuscular injections of botulinum neurotoxin (

BoNT

) serotypes

Outcomes

Primary: Symptoms (pain intensity), disability, overall improvement or proportion of patients recovered, back-specific functional status, well-being

Secondary: Physiological outcomes, satisfaction with care, adverse events

Slide3

3 trials (123 participants) included

Results & Conclusions

Interventions

Evidence

Quality

of evidence

BoNT

injections

More effective than saline injections for pain and function in the short and intermediate-term but not in the long-term

Very low to Low

More effective than traditional acupuncture for reducing pain and improving function in the intermediate-term but no differences in the short and long-term

Very lowMore effective than corticosteroid injection for reducing pain in the short-term but not in the long-termVery low

Botulinum toxin injections for low back pain Waseem et al (2011)

Adverse events: A few cases of worsening pain after injection in both experimental and control groups

There is very low to low quality evidence that botulinum toxin injection is better than other injections in improving pain and function