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Botulinum toxin injections for low-back pain and sciatica
Waseem et al (2011)
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Slide2Botulinum toxin injections for low back pain
Waseem et al (2011)Overview of the study
Objectives To determine the effects of botulinum toxin injections in adults with low back pain (LBP)Methods Evidence current up to 1 February 2010 Participants: Adults (18 and older) with non-specific LBP and/or sciatica (acute, subacute, or chronic)
Interventions: All intramuscular injections of botulinum neurotoxin (
BoNT
) serotypes
Outcomes
Primary: Symptoms (pain intensity), disability, overall improvement or proportion of patients recovered, back-specific functional status, well-being
Secondary: Physiological outcomes, satisfaction with care, adverse events
Slide33 trials (123 participants) included
Results & Conclusions
Interventions
Evidence
Quality
of evidence
BoNT
injections
More effective than saline injections for pain and function in the short and intermediate-term but not in the long-term
Very low to Low
More effective than traditional acupuncture for reducing pain and improving function in the intermediate-term but no differences in the short and long-term
Very lowMore effective than corticosteroid injection for reducing pain in the short-term but not in the long-termVery low
Botulinum toxin injections for low back pain Waseem et al (2011)
Adverse events: A few cases of worsening pain after injection in both experimental and control groups
There is very low to low quality evidence that botulinum toxin injection is better than other injections in improving pain and function