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Antibody B cell checkpoints in autoimmune SamuelJSRubin MichelleSBloom and WilliamHRobinsonAbstract B cells have important functions in the pathogenesis of autoimmune diseases including. T. h. e Specific Immune Response. OCR AS Biology – F212 – Module 2. Food & Health. Learning Objectives. Success Criteria. Understand the role of the specific immune system.. Understand the role of B and T Lymphocytes in fighting off pathogens.. T. h. e Specific Immune Response. OCR AS Biology – F212 – Module 2. Food & Health. Learning Objectives. Success Criteria. Understand the role of the specific immune system.. Understand the role of B and T Lymphocytes in fighting off pathogens.. of B and T cell . Markers in Chronic Granulomatous Disease (CGD) Patients. Faculty of Medicine. By.   . Reem. J. . Farid. *; . Safa. S. . Meshaal. *. ; . Rabab. El . Hawary. *. ; . Engy. M. . Fekry. Lesson Objectives:. Describe the different forms of immunity in the body. . . (AO1. : . D). Describe what is meant by ‘. phagocytosis. ’ and how it acts as a defence mechanism. . (AO2. : . C. ). Explain the role of . Specific Defences. (e). Autoimmunity & Allergies. (. a. ) Immune Surveillance. (b) Clonal Selection Theory. KA2: Specific Defences. (d) Immunological Memory. (c) T and B Lymphocytes. By the end of this section you will be able to ….. . GENESIS. 1.Lymphoblast. :15-20 micrometer. Large nucleus with rarely more than 2 distinct. nucleoli. Cytoplasm is blue as a narrow rim around the. large nucleus. Prolymphocyte. :. Prolymphocyte. :. GENESIS. 1.Lymphoblast. :15-20 micrometer. Large nucleus with rarely more than 2 distinct. nucleoli. Cytoplasm is blue as a narrow rim around the. large nucleus. Prolymphocyte. :. Prolymphocyte. :. What are lymphocytes?. Lymphocytes. are a type of white blood cell (. leukocyte. ) found in the blood and lymph nodes. . Collectively, lymphocytes can recognize millions of different antigens, due to the large variation of lymphocytes produced. . the Division of Hematology Department of Medicine Geneva University Hospital 1211 Geneva 4 Switzerland of mRNA for eight cytokines was analyzed in an in vitro response-proliferation and Ig-secretion- Distinguish . between our own cells and antigens! . Through MHC molecules . MHC class-I . vs. MHC class-II. MHC-II molecules are expressed on : . HLA : human leukocyte antigens . About MHC-II genes. , . their. . characteristics. . and. . function. . . Interferons. .. 9. HLA . system.   (. classes. , . polymorphism. , . typing. ).. 10. . Binding. . of. . peptides. to MHC. Antigen . presentation. Immune System. (organs). Dr. Mustafa Jawad. Introduction. . The immune system comprises a variety of organs which are concerned with growth . and development . of immunocompetent cells. These are lymphoid . CLICK TO ENGAGE HYPERDRIVE. CELLS OF THE IMMUNE SYSTEM. BASOPHILS. Basophils are a granular, bone-marrow derived leukocyte that are closely related to mast cells. Whereas mast cells are found in the tissues, the basophils circulate round the body and release histamine when activated, resulting in the signs of inflammation and allowing other cells of the immune system to be recruited to the site of damage or infection.. Dr. Mustafa Jawad. Cells of immune system. 1. . . Functional cells. a. Lymphocytes. .. b. Plasma cells.. c. Phagocytic cells..  Macrophages.  Neutrophils.  Eosinophils.  Dendritic cells..