PPT-Neurogenic Inflammation and Migraine

Zeinab Ghorbani PhD Candidate in Nutritional Sciences School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences TUMS Introduction Top 10 level4 causes of disability in GBD 2016 global both sexes all ages. Kevin M Kapadia, MD. Meriter Medical Group Neurology. Madison, WI. Objectives. Headache Disorders comprise a large portion of inpatient and outpatient primary care, pain medicine, and neurologic care, of which migraine headache disorders are one of the most common.. My head doth ake . O Sappho! Take . Thy fillit, . And bind the paine; . Or bring some bane . To kill it.. Robert Herrick (1591–1674). The Head-ake. History. Migraines described by Egyptians as early as 1200 BCE. David Watson, MD. Director, WVU Headache Center. EPIDEMIOLOGY . AND IMPACT. Resolving barriers to care requires several interventions. Migraine is . a common, often disabling disease of the nervous system. Gaston. Migraines. Chief Complaint. : “ I’ve . been having really bad headaches that won’t go away.”. HPI. : Patient . L.R. . . is a . 28 . year old Caucasian . female . that presents to the clinic with complaints . 10-12% of general population are active migraineurs (at least one attack in last year).. > 5% have at least 18 migraine days per year.. Female: Male ratio 3:1 – this ratio rises from menarche, peaks at 42, then declines.. Iman Adibi. Department. of . Neurology. , . Isfahan. . Luniversity. of . Medical. Sciences . Global Burden of Disease Study 2010 . Migraine. Tension Headache. Depression. What is the epidemiology of comorbid migraine and depressive disorders? . CLINICAL CONDITIONS . IN WHICH 5-HT . PLAYS A ROLE . (. carcinoid syndrome and pulmonary . hypertension. .). The . most common types of headaches . are: . migraine, tension-type, . and cluster . headaches.. Dr. . Shakir. H. Mohammed . Al_Alwany. LEC 2,3,4. Hyperplasia & Physiologic . Hyperplasia. HYPERPLASIA . Increase . in the number of cells . results in increase in size of the . organ. Migraine without aura. ≥5 . attacks. lasting . 4–72 hours . when untreated. ≥. 2 . of the following. : . Unilateral location. Pulsating quality. Moderate-to-severe pain. Aggravation by physical activity. A person may experience migraine both with and without aura, and the aura experience varies between and within individuals. 1. Compared with migraine without aura, migraine with aura appears to have:. Migraine is a chronic neurological disease with episodic attacks of head pain. 1. If caused by another medical condition, the headache is said to be a secondary headache. 2. Migraine is characterised, including by . *p<0.05, **p<0.01, ***p≤0.001; values shown in black are odds ratios comparing chronic migraine and episodic migraine. AMPP=American Migraine Prevalence and Prevention; COPD=chronic obstructive pulmonary disease; PHQ-9=Patient Health Questionnaire – 9 items. An electronic diary study followed 62 people with migraine over 3 months. 1. The most the frequent trigger factors on headache days were . stress. , . fatigue. , and . sleep deprivation. 1. Headaches with trigger factors were more severe than those without trigger factors. 1. Turner et al. Headache 2019;59(4):495–508; 2. . Wöber. et al. J Headache Pain 2006;7(4):188–195; 3. . Pavlovic et al. Headache 2014;54(10):1670–1679; 4. . Sarchielli. . J Headache Pain 2006;7:172–173; .