PPT-Treatment of Imatinib -resistant GIST

The Next Generation Dr Michael Heinrich MD OHSU Knight Cancer Institute Portland OR Background Small molecule kinase inhibitors of KITPDGFRA such as imatinib and sunitinib have transformed the medical treatment of advanced GIST. Resistance. Geoffrey L. Uy, M.D.. Associate Professor . of Medicine. Division of Oncology. Natural History of CML. Chronic Phase. Accelerated Phase. Blast Phase. Duration. 3-5 . yrs. , untreated. Varies. . Janghorban. CANB610. 3/8/2012. ETV1 and GIST Pathogenesis. Gastrointestinal . stromal. tumors (GISTs) arise from the interstitial cells of . Cajal. (ICC) in the gastrointestinal tract . Most GISTs have oncogenic mutations in either KIT or platelet-derived growth factor receptor-α (PDGFRA); ~80-85%. Evidence-based Management . of GIST. Program Goals. GIST. Current Treatment Paradigm. What is GIST?. What Causes GIST?. GIST: Treatment. Polling Question #1. Imatinib: Clinical Trial Results. Imatinib: Early Stage GIST. (aka---how to know where to look and who to call). GIST. Rare disease, 5000-7000 new cases of GIST every year . Compare 230,000 new invasive breast CA cases/year. GIST studies tend to be opened at fewer sites . Cara Peters. cpeters3@math.umd.edu. Advisor: Dr. . Doron. Levy. dlevy@math.umd.edu. Department of Mathematics. Center for Scientific Computing and Mathematical Modeling. Introduction. CML – cancer of the blood. Sarcoma . Medical Oncology. The University of . Miami, Sylvester Cancer Center. Gastrointestinal Stromal . Tumor. Advanced Disease. jtrent@med.miami.edu. Background and Introduction. 4000 to 6000 new GIST are diagnosed in the United States each yr. Associate Professor . of Medicine. Division of Oncology. Natural History of CML. Chronic Phase. Accelerated Phase. Blast Phase. Duration. 3-5 . yrs. , untreated. Varies. Median. of months. Prognosis. Tim Bowersox, Cyril Oberlander, Kate Pitcher, Mark Sullivan. State University of New York, Geneseo College. Getting It System Toolkit. Enhancing user experience. and customizing a future for ILL & Acquisition. Lillian Klug, PhD . Post-doctoral Scholar, Heinrich Lab. GCRF conference | May 8, 2018. Gastrointestinal stromal tumor (GIST) is a unique disease. GIST is caused by mutations in DNA. Mutations in DNA can turn on the activity of proteins that are normally not active in adults= . Global Fire Resistant Cable Market Size, Share, Industry Trends, Growth, Outlook & Analysis 2017-2027 By Insulation Material (Cross-Linked Polyethylene (XLPE), Polyvinyl Chloride (PVC), Low Smoke Zero Halogen (LSZH), Ethylene Propylene Rubber (EPR), and Others); By End-Use Industry (Building & Construction, Manufacturing, Energy, and Others); By Region, Competitive Market Share & Forecast I. ntroduction. CML is a clonal myeloproliferative neoplasm. Dysregulated production and uncontrolled proliferation of mature and maturing granulocyte with fairly normal differentiation. Fusion of 2 genes: BCR (or chromosome 22) and ABL1 (on chromosome 9), resulting in BCR-ABL1 fusion gene. A FIP risk criteria 3 ears of imatinib (n= 31) 5 Y ears of imatinib (n= 20) p - value 2 0 1 (5.0 ) 0. 7 3a ) 3 (15 ) 3b 9 (29 ) ) 5 0 1 (5.0 ) 6a 11 (35 ) 6 (30 ) 6b 6 (19 ) 5 (25 ) Vpresented as nu Dr. Sonalika’s Eye Clinic provide the best Cataract Phaco Surgery, Cataract surgery treatment in Pune, Hadapsar, Amanora, Magarpatta, Mundhwa, Kharadi Rd, Viman Nagar, Wagholi, and Wadgaon Sheri Dr. Sonalika’s Eye Clinic provide the best Phaco surgery treatment in Pune, Hadapsar, Amanora, Magarpatta, Mundhwa, Kharadi Rd, Viman Nagar, Wagholi, and Wadgaon Sheri