Collegium Ramazzini October 2016 Arthur L Frank MD PhD There continues to be legitimate questions in the area of asbestos science Fiber toxicity Fiber size Genetics Multiple factor interactions ID: 553485
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Asbestos fiber burden as the gold standard: another perversion of scienceCollegium Ramazzini– October 2016
Arthur L. Frank, MD, PhDSlide2
There continues to be legitimate questions in the area of asbestos science
Fiber toxicityFiber sizeGeneticsMultiple factor interactionsSlide3
There also continues to be a travesty of science with illegitimate views.Chrysotile does not cause mesothelioma
Brakes do not cause diseaseOne needs to study each product or job categoryDifferent populations do not get disease
“Safe Use”Slide4
We must remember the classic Ramazzini question.Slide5
The True Gold StandardVan
Cleemput et al – Am. J. Resp. Crit. Care Med. 165:134, 2002Slide6
Problems with Fiber BurdenNo standard methodology
Altering technique (e.g.: pore size)Chrysotile issueTime since last exposureWhat tissue to evaluate (lung, pleura, other)
What fiber size to countSlide7
Except in legal circles everyone agrees on the hazards
of Chrysotile.(NIOSH, OSHA, EPA, IARC, WHO, CR, Epi Societies)Slide8
As a practical matter, what would a tissue burden analysis mean if required:
Fewer people compensatedDisturbances of buried bodiesPossible bizarre requirements (like dose reconstructions)Slide9
We do not use this kind of false proof for other malignancies – cigarettes and its chemicals, radiation in tissue, arsenic, etc.Slide10
The “Science for Sale” people would win!Slide11
We still need to pushfor a complete ban.