PPT-Identifiability of linear compartmental models

Nicolette Meshkat North Carolina State University Parameter Estimation Workshop NCSU August 9 2014 78 slides Structural Identifiability Analysis Linear Model state variable input. Linear models are easier to understand than nonlinear models and are necessary for most contro l system design methods brPage 2br Single Variable Example A general single variable nonlinear model The function can be approximated by a Taylor seri JACQUEZ Department of Physiology The Unioersify of Michigan Ann Arbor Michigan 48109 0010 AND PETER GREIF LahoratorJ of Mathematical Biology National Cancer Institute Naiional Instrtutes of Health Bethesda MaTland 20205 Received 20 November 1984 rev That is the data do not MARK permit the estimation of some parameters This is an inherent lack of information that keeps some parameters from being estimated The issue is like the estimation of the regression model E yx when the sample size 1 In this graphical representation denotes the slope of the line and denotes the intercept the value of when equals zero This equation can also represent a model To do this the line is interpreted in such a way that the value of depends on the value o 2 pp 1 a 3 1999 A comment about estimable functions in linear models with non estimable constraints Un comentario sobre las funciones estimables en modelos lineales con contrastes no estimables Fabio Humberto Nieto Universidad Nacional de Colombia B Richard Mott. Wellcome Trust Centre for Human Genetics. Recap. So far, we have learnt about. Correlation. Linear Regression. One-Way Analysis of Variance. Non-parametric alternatives. In this lecture we will cover. models. Jeremy Groom, David Hann, Temesgen Hailemariam. 2012 Western . Mensurationists. ’ Meeting. Newport, OR. How it all came to be…. Proc GLIMMIX. Stand Management Cooperative. Douglas-fir. Improve ORGANON mortality equation?. . A . full-scale case . demonstration. U. Rehman. 1). , . W. Audenaert. 1). , C. De Mulder. 1). , Y. Amerlinck. 1. ). , M. . Arnaldos. 2). , S. R. Weijers. 3). , O. Potier. 4). , I. Nopens. 1). 1) BIOMATH, Department of Mathematical Modelling, Statistics and Bio-Informatics, Gent, Belgium.. models. Jeremy Groom, David Hann, Temesgen Hailemariam. 2012 Western . Mensurationists. ’ Meeting. Newport, OR. How it all came to be…. Proc GLIMMIX. Stand Management Cooperative. Douglas-fir. Improve ORGANON mortality equation?. Specific PMLC models. Agenda. Tuesday – . Announcement(s). House Cleaning. Class Evaluation. . Specific PMLC models. Thursday – . Team Time/Mentor meeting. Copyright Tom Sulzer © 2018. Introduction. -A short summary . RG . Baraniuk. , MK . Wakin. Foundations of Computational Mathematics. Presented to the . University of Arizona. Computational Sensing Journal Club. Presented by Phillip K . Poon. M.J.Chappell@warwick.ac.uk. Structural . Identifiability. Analysis. What are compartmental models?. Consist of finite number of . compartments. homogeneous, well-mixed, lumped subsystems. kinetically the same. 25.05.12. 1. Angelina Fahmay . AZT Case study. 1) Involving 100mg AZT. :. 24 healthy subjects. (12 Female, 12 Male) . Weights of healthy subjects (Range: 50-77kg) (Average: 62kg) . Given . FOUR different . Presented by:. Oyeboade . R. Kiitan 17/eng08/004. Biomedical . Engineering. BME312. Biological system of control and Modelling. 1. INTRODUCTION. One- . and two-compartmental models of haemodialysis (HD) are well .