PPT-Stem Cells and Cell Signaling

ChengEn Lai BIOE 506 Molecular and Cellular Bioengineering 4252011 Overview Background Stem Cells Signaling Pathways Transforming Growth Factor β TGF β SMAD Signaling Pathway. Greg, Lauren, Nancy, Mark, Gene. Facilitator: Paula. Level. Introductory biology. Knowledge of students prior to unit. Cell theory. Characteristics of life. Homeostasis . Chemistry of macromolecules. 2008;36:536–541. Before 2004 :. Apexification. :. Apexification. has proven to be highly predictable . increased susceptibility to cervical fracture . The . artificial. apical barrier technique . Recurrence and Metastasis: A Major Factor in Cancer-related Deaths. Cancer is the second leading cause of death in the United States. 1. Despite advances in cancer treatment, many patients develop:. Cell-to-cell . signaling. : . Important . to both multicellular . & unicellular . organisms. . H. elps coordinate activities & . events necessary for . multicellular . organism to develop from . Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Cheng-En Lai. BIOE 506: Molecular and Cellular Bioengineering. 4/25/2011. Overview. Background. Stem Cells. Signaling Pathways. Transforming Growth Factor-. β. (TGF-. β. ). SMAD Signaling Pathway. Facilitator: Paula. Level. Introductory biology. Knowledge of students prior to unit. Cell theory. Characteristics of life. Homeostasis . Chemistry of macromolecules. Cell Signaling. Learning Goals:. ACTUAL DEFINITION . - An undifferentiated cell of a multicellular organism that is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cell arise by differentiation.. A stem cell is . a . “blank” cell. It can divide and produce identical . . copies – Self Renewal . P. rocess. Serves as a built-in repair system for . . . human . body. What Stem Cell does?. iPS. cells, self-renewal, differentiation, pluripotent, multipotent, Inner cell mass, Nuclear transfer (Therapeutic cloning), Feeder cells, LIF, embryoid body.. What are stem cells?. Cells that are able to renew themselves (. is. 1- . a . non-specialized. , . 2- generic . cell which can make exact copies of. itself . indefinitely and. 3- . can differentiate and produce specialized cells for the . various tissues . of the . DR. AYSER HAMEED. LEC.5. Tissue repair is critically influenced by the intrinsic proliferative capacity of the constituent cells. Based on this criterion, the tissues of the body are divided into three groups:. Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . Lecturer . Dr. Samah A. Jassam BSc MSc PhD . MRSB. Al-Mustansiriya University . Collage of Pharmacy. Two . major types of stem cells in . mammals:. 1- . Embryonic . stem cells. , that are isolated from the inner cell mass of .