August 25 2022 Aivija Grundmane TRIUMFSimon Fraser University Carbo Bague et al Encyclopedia of Inorganic and Bioinorganic Chemistry 2021 MeitnerAuger Emitters for Targeted Radionuclide Therapy ID: 1036567
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1. Purifying Radioantimony for Targeted Radionuclide Therapy: Developments in Separating Antimony from Bulk Tin TargetAugust 25, 2022Aivija Grundmane, TRIUMF/Simon Fraser University
2. Carbo-Bague et al, Encyclopedia of Inorganic and Bioinorganic Chemistry, 2021.Meitner-Auger Emitters for Targeted Radionuclide TherapyS. Aghevlian et al, Adv. Drug Deliv. Rev. 2017, 109, 102–128.2
3. Sb 11938.19 hεγ 24, g Appropriate half-life for TRTAbsence of other accompanying emissionsGood number and energy of Meitner-Auger electronsIsotopeHalf-lifeMAE/decayEavg (keV/decay)High E γ119Sb38.2 h23.78.9No197gHg2.67 d23.27.4No197mHg23.8 h19.47.6Yes111In2.81 d14.76.75Yes125I60.1 d24.912.24NoRandhawa et al, Curr. Radiopharm., 2021, 14, 394 - 419Symochko et al, 2009, 110(11), 2945 - 31053
4. Irradiation of natSn at TRIUMFnatSn target irradiated with 12.8 MeV protons (TR13) at 5 A for 60 min50 MBq of 119Sb (t1/2 = 38.19 h) 1.5 MBq of 120mSb (t1/2 = 5.76 d) and 28 kBq of 117mSn (t1/2 = 14.0 d)natSn targetIsotopeNatural abundance (%)Sn-117g7.68Sn-11824.22Sn-1198.59Sn-12032.58Sn-122Sn-1244.635.794
5. Radiochemical Separation – Liquid-Liquid ExtractionSbSbSbSbSbSbSbSbRemoves > 99.95% of the tin target> 75% recovery of radioantimonyLimitations inherent to the methodology (dilute Sb, high hand dose, large volume of waste)~400 mg Sn< 200 μg Sn5
6. Radiochemical Separation – Column ChromatographyIdeal separation:Concentrated Sb-119 No oxidation/reduction requiredHigh separation factorEasy to automate6
7. Dibutyl Ether Resin in Development7Dibutyl Ether ResinResin Beads +Irradiated Sn target (400 mg), γ spectroscopy, n = 3.
8. Dibutyl Ether Resin in Development8Resin Beads +Dibutyl Ether ResinIrradiated Sn target (400 mg), 0.5 mL elution steps, γ spectroscopy.
9. Future Direction9Resin characterisationRadiolabeling studiesOptimizing antimony elution conditions
10. 10Thanks toDr Valery RadchenkoDr Caterina RamogidaThe Ramogida GroupTR13 Team Scott McNeilAeli OlsonDr Tom Kostelnik