PPT-Penicillins ( Part 1)

. 4http://www.ific.org,http://www.cfsan.fda.gov/˜dms/foodic.html5http://www.google.com patternfreq. part inftheg? whole 488 part forfuseinjmakingg? whole 129 part -fortied whole 74 part from whole Dr. Bilal Aljaidi. Antibacterial agents:. Antibiotic: . any substance produced by a microorganism that is antagonistic to the growth of other microorganisms (mainly bacteria) in high dilution (Waksman 1942).. Dr. Naila Abrar. LEARNING OBJECTIVES. After this session you should be able to:. know the source & chemistry of penicillins;. recall the morphology of bacterial cell wall;. c. lassify penicillins;. 84. Drugs That Weaken the Bacterial Cell Wall I: Penicillins. Penicillins. Active against a variety of bacteria. Direct toxicity: low. Principal adverse effect: allergic reaction . Beta-lactam ring in their structure. For this. Deadens the heart. . (Tirmidhi). Hadith Shareef. β-Lactam Antibiotics. Penicillins. Cephalosporins. Monobatams. Carbapenems. 3. Penicillins. . Short History . 4. Brief History. Paul Ehrlich . as salicylic acid and its derivatives e.g. aspirin, and . paracetamol. , . block the transmission of pain from source . i.e. the injured tissue to . brain as they intercept the pain stimulus . at source. . Assistant Professor Dr. . Naza. . M. Ali. . Lec. 3. 24 Oct 2019. Cell wall. The cell wall is a rigid outer layer, it completely . surrounds the . cytoplasmic membrane, maintaining the shape of the cell . Assistant Professor Dr. . Naza. . M. Ali. . Lec. 3. 24 Oct 2019. Cell wall. The cell wall is a rigid outer layer, it completely . surrounds the . cytoplasmic membrane, maintaining the shape of the cell . Chapter 7. Antibacterial Drugs That Disrupt the Bacterial Cell Wall. Introduction to Penicillins. Group of antibiotics for treatment of susceptible pathogens. Actions: cell wall synthesis; DNA or RNA synthesis; protein synthesis . Penicillins. ) And beta . lactamase inhibitors. Dr.. Rashmi . Rekha. Kumari. Asstt. . . Prof.. cum Jr. Scientist. Deptt. . Of . Vety. . Pharmacology and Toxicology. B.V.C, . BASU,Patna. Pharmacokinetics. ……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………. DRUG ACTION: The penicillins are . bactericidal. and act by interfering with bacterial cell wall synthesis. They diffuse well into body tissues and fluids, but penetration into the cerebrospinal fluid is poor except when the meninges are inflamed. They are excreted in the urine in therapeutic concentrations.. synthesis . of . the bacterial cell . wall—a structure that . mammalian . cells do not possess. . The cell . wall is . composed . of a polymer called . peptidoglycan. that . consists of . glycan. units joined to each other by . atelectasis. ..