PPT-Elvitegravir-Cobicistat-TAF-FTC in Renal Impairment

Study 112 ElvitegravirCobicistatTAFFTC in Renal Impairment Study 112 Design Source Pozniak A et al J Acquir Immune Defic Syndr 2016715307 Baseline ART n 242 Study Design Study 112. Study GS-US-292-0119. E/C/F/TAF + DRV 800 mg QD. N = 89. N = 46. Baseline regimen. Design. Randomisation*. 2: 1. Open-label. Objective. Primary Endpoint: proportion with treatment success (HIV RNA < 50 c/mL) . Treating and Preventing HIV in 2019: Interactive Cases From the Clinic(ians) Michael S. Saag , MD Professor of Medicine Associate Dean for Global Health Jim Straley Chair in AIDS Research University of Alabama at Birmingham Progressive rises in weight and clinical obesity for TAF/FTC+DTG and TDF/FTC+DTG versus TDF/FTC/EFV: ADVANCE and NAMSAL trials Andrew Hill, Francois Venter, Eric Delaporte , Simiso Sokhela, Charles G-103 Ckbeceopap (Pubkop( CO>E) (Last updated December 24, 2019, last reviewed December 24, 2019)Carcinogenicity Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infectio www.hivguidelines.org. Purpose of . This Guideline. Provide a clear and concise roadmap for clinicians to follow in choosing from among several equally efficacious ART regimens based on individual patient characteristics and preferences.. Joseph J. Eron, Jr, MD. Professor of Medicine. University of North Carolina. Chapel Hill, North Carolina. Panelists. Constance Benson. Hyman Scott. Annie . Luetkemeyer. Robert . Schooley. Financial Relationships With Commercial Entities. in a Single-Tablet Regimen . in Initial HIV-1 Therapy. Combined Primary Results of . Studies GS-US-292-0104 and GS-US-292-0111. David Wohl. 1. , Anton Pozniak. 2. , Melanie Thompson. 3. , Edwin DeJesus. Tenofovir. . Alafenamide. . vs. . Tenofovir. . Disoproxil. . Fumarate. Combined Safety Results of . Studies GS-US-292-0104 and GS-US-292-0111. Paul Sax. 1. , Michael Saag. 2. , Michael Yin. 3. , Frank Post. Lille 27. th. March 2019. ERA Telematics Team. 1 - Project Initiation. Project Requirements. To make it easy and . understable. for all companies in particular small and medium size.. Business Case. Study 1249. Elvitegravir-Cobicistat-TAF-FTC in HIV/HBV Coinfection . Study 1249: . Design. Source: Gallant J, et al. . J. . Acquir. Immune . Defic. . Syndr. . 2016;73:294-8.. Baseline ART. (n = 72). and . Virologic. Outcomes . for Treatment-experienced . People Living with HIV Switching to MTR or STR ART since 2018 . Ben Chastek. 1. , Amy Anderson. 1. , Joshua Gruber. 2. , Sunil Majethia. 2. , Woodie Zachry. ADVANCE. . Design. Primary endpoint. Proportion of patients with HIV RNA < 50 c/mL at W48, ITT-E snapshot analysis ; non-inferiority of TFA/FTC if lower margin CI for . the difference = - 10%, 80% power. FTC. Study 311-1089. Switching from TDF/FTC to TAF/. FTC. Study 311: Design. Source. : Gallant JE, et al. Lancet HIV. 2016;3:e158-65.. Switch to TAF/FTC*. . (n = 333). Continue TDF/FTC. (n = 330). *Patients on a pharmacokinetic booster (ritonavir) received tenofovir alafenamide-emtricitabine 10/200 mg. Study 105. Atazanavir + [Cobicistat or Ritonavir] + TDF-FTC (Phase 2). Study 105: Study Design. Source: . Elion. R, et al. AIDS. 2011;25:1881-6. . Background. : Randomized, partially placebo-controlled, double-blind phase 2 trial to compare the safety and efficacy of cobicistat and ritonavir as pharmacokinetic enhancers administered with atazanavir and fixed-dose tenofovir DF-emtricitabine in treatment-naïve adults with HIV infection.