PPT-Irradiation of Blood and Blood Components

Why to Irradiate blood Transfusion Associated Graft versus Host Disease TAGVHD Indications of Irradiated Components Shelf Life of Irradiated products Methods of Irradiation Contents For Prevention of . 1 Prepared by the BCSH Blood Transfusion Task Force Address for correspondence: BCSH Secretary British Society for Haematology 100 White Lion Street London N1 9PF e - mail bcsh@b - s - h.org.uk Writi Why we should not use whole blood. Whole blood has plasma which is a source of numerous infections and antibodies not native to the recipient.. Plasma of whole blood does NOT have any platelet , coagulation factors because stored blood at 2-8 C loses all the above components.. Dr Nishant Verma. Department of Pediatrics,. KGMU, Lucknow. Historical Time Line. 17. th. century- 1. st. recorded transfusion (from man to animal). 1901- Karl Landsteiner’s discovery of ABO grouping laid foundation for scientific transfusion practices. Department of Pediatrics,. KGMU, Lucknow. Historical Time Line. 17. th. century- 1. st. recorded transfusion (from man to animal). 1901- Karl Landsteiner’s discovery of ABO grouping laid foundation for scientific transfusion practices. on behalf of the Irradiation WG. April 16. th. , 2015. 1. Irradiation Guidelines. NAC Draft Irradiation Guidelines have been resurrected due to:. An interest in changing the CSA standard around irradiation parameters so that the standards reflect the European practice that is more appropriate for SAGM red cells.. Blood transports everything (nutrients, wastes, and body heat). Blood is a complex fluid connective tissue with both solid and liquid components.. Solid – living blood cells (formed elements). Erythrocytes (red blood cells –RBCS). elements-Cells . Erythrocytes (RBCs). Leukocytes (WBCs). Thrombocytes. (platelets. ). Plasma. 90% water. 10% solutes. Proteins, clotting factors. 1. What can we give?. Whole blood. Packed RBC (PRBC). in children. . Packed cell, platelet, FFP, cryoprecipitate, WBC. Packed red cell. Transfusion. Packed red cells. . Average hematocrit of a unit is 65-75%. ( concentrated). Estimated unit size : 250-350 cc. blood is collected as whole blood, as shown below:. Blood can be stored as whole blood (with all of the plasma present) or, much more commonly, as packed red blood cells (PRBC's) in which about 70% of the plasma has been removed.. Speakers from the Center for Biologics Evaluation and Research of the Food and Drug administration contributed to the September 2009 public workshop on licensure and thus to the contents of this book.--p. [iii] This guidance is based on the National Blood Transfusion Committee (NBTC) Indication Codes for Transfusion ( January 2020) The indications for transfusion provided below are taken from national gui Fluids of the Body . Cells of the body are serviced by 2 fluids. blood. composed of plasma and a variety of cells. transports nutrients and wastes. interstitial fluid. bathes the cells of the body. Nutrients and oxygen diffuse from the blood into the interstitial fluid & then into the cells. 55% plasma. 45% cells . 99% RBCs. < 1% WBCs and platelets. Formed Elements of Blood. Red blood cells ( erythrocytes ). White blood cells ( leukocytes ). granular leukocytes. neutrophils. eosinophils. Erythrocytes (RBCs). Leukocytes (WBCs). Thrombocytes. (platelets). Plasma. 90% water. 10% solutes. Proteins, clotting factors. 1. What can we give?. Whole blood. Packed RBC (PRBC). Platelets. Fresh Frozen Plasma (FFP).