PDF-NonparametricEstimationofMaximumToleratedDose(MTD)intheContextofPhaseI
1IntroductionDoseresponsedesignandstudiesareconductedinphaseIclinicaltrialstostudytoxicityinthedrugdevelopmentprocessSequentialresponsedrivendesignsareusuallycarriedoutforthispurposeThepatientsare
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