Aphthous fever FMD الحمى القلاعية Bibliotheca Alexandrina 1832012 Epizootic events US 19141929 UK 1967 Taiwan 1997 UK 2001 China 2005 UK 2005 Japan and Korea 20102011 ID: 240747
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Foot and Mouth Disease Aphthous fever FMDالحمى القلاعية
Bibliotheca Alexandrina
18/3/2012Slide2
Epizootic events US 1914-1929UK 1967Taiwan 1997UK 2001China 2005UK 2005
Japan and Korea 2010/2011Bulgaria 2011Slide3
EGYPT 2006Epizootic events
Losses up to 900.000 headSlide4
What is FMD? VIRALSlide5
SusceptibilityCLOVEN HOOF
ذوات الظلف المشقوق Slide6Slide7
Taxonomy أصله وفصلهPicornaviridae
Picorna virus
Aphthous virus
FMD VIRUS
O
A
C
SAT1
SAT2
SAT3
ASIA1Slide8
Physico-chemical properties ?PH : stable at 7.4-7.6 . . . . ! ! Resistant to :ChloroformEtherBile saltsDetergents ????Slide9
Virus Structure
General virus structureSlide10Slide11
Virus Structure1.Capsid الإطار الخارجى
2.Viral proteins :
VP1
VP2
VP3
VP4
3. Nucleic Acid “RNA”
ANTIGENICITY
إحداث المرضSlide12
Genetic Material
Viral
proteinsSlide13
Understanding infectionSlide14
Why Antigenic Variation??!!Millions of copies + narrow time + LACK OF CORRECTION =
Evolution of New SubtypeSlide15
Point mutationWhy Antigenic Variation??!!Slide16
Why Antigenic Variation??!!
Point mutationSlide17
PrognosisMorbidity: 100%Mortality: up to 5%
50-70% in calves
up to 100% in suckling calvesSlide18
Mode of Transmission Slide19
Mode of Transmission Quantitative risk assessment of FMD virus transmission via water.National Institute of HealthUSASlide20
Clinical Signs الأعراض الإكلينيكية Slide21
Clinical Signs الأعراض الإكلينيكية Slide22
Clinical Signs الأعراض
الإكلينيكية
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Clinical Signs الأعراض
الإكلينيكية
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Clinical Signs الأعراض الإكلينيكية Slide25
P.M ExaminationCalf heart if passed: MYOCARDIOPATHYSlide26
How to control ?Isolation of suspected casesSlide27
How to control ?VaccinationHow to control ?
Matching and
selection ..
Emergency vaccination ..
Protective Vaccination
Vs
Suppressive Vaccination . .Slide28
How to control ?Biosecurity proceduresSlide29
How to control ?Biosecurity proceduresSlide30
How to control ?Biosecurity proceduresSlide31
Public Health concern . . Zoonotic in very limited conditions ??
Milk. . If unboiled !
Occupational . . Vets ! Slide32
Public Health concern . . Zoonotic in very limited conditions ??Slide33
Syndicate Axial Role Slide34
Referenceshttp://www.oie.int/eng/A_FMD2012/docs/2.01.05_FMD.pdfhttp://www.fao.org/ag/againfo/commissions/docs/training/material/Diagnostic_sampling_procedures/Diagnostic_sampling_procedures.pdfhttp://www.daff.gov.au/animal-plant-health/pests-diseases-weeds/animal/fmd
http://veterinaryextension.colostate.edu/News/dzinfo/Japan%20FMD%20_2_1%20_2_.pdf