Introduction How Has Precision Medicine Changed the Treatment Landscape in Oncology Selection of Biomarkers in Drug Development Methods to Identify Driver Mutations Which Method Should Be Used ID: 777458
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How Can Precision Medicine in Oncology Refine Best Treatment Approach?
Slide2Introduction
Slide3How Has Precision Medicine Changed the Treatment Landscape in Oncology?
Slide4Selection of Biomarkers in Drug Development
Slide5Methods to Identify Driver Mutations
Slide6Which Method Should Be Used?
Slide7Challenges With Testing Methods in Precision Medicine
Slide8Novel Targets: NTRK
Slide9Novel Targets
Slide10Estimated Frequency of TRK Fusions Varies Across Tumor Types
Slide11Active Clinical Trials of TRK Inhibitors in Patients With NTRK Fusion Tumors
Slide12Entrectinib Studies
Slide13Best Response to Entrectinib in Patients With TKI Treatment-Naive Extracranial Solid Tumors
Slide14Larotrectinib Basket Trials
Slide15Clinical Efficacy of Larotrectinib in NTRK
Fusion Cancers
Slide16Integrated Clinical Development of Larotrectinib Simultaneously Across Adult and Pediatric Cancers
Slide17NTRK Testing Options
Slide18Pan-TRK IHC Staining Concordance With RNA Testing
Slide19Conclusions
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