PPT-Pathophysiology of Type 1 Diabetes

1 Type 1 Diabetes Mellitus Characterized by absolute insulin deficiency Pathophysiology and etiology Result of pancreatic beta cell destruction Prone to ketosis Total deficit of circulating insulin. of Type 1 Diabetes. Type 1 Diabetes Mellitus. Characterized by absolute insulin deficiency. Pathophysiology and etiology. Result of pancreatic beta cell destruction. Prone to ketosis. Total deficit of circulating insulin. Weirui. Chai. 4/12/2011. Content. Diabetes – High Blood . Sugar. Type 1 and Type 2 . Diabetes. Treatments for Type 2 . Diabetes. Conclusion. Diabetes – High Blood Sugar. Diabetes . mellitus:. A . George L. King MD. Joslin Diabetes Center . Harvard. Medical School. Type 2 diabetes. . >. 90% of total . (>95% in AA). Mostly in adults, . but increasing in children. Not insulin requiring. Insulin resistant (IR). 1. Risk Factors for Prediabetes and Type 2 Diabetes. Family history of diabetes mellitus. Cardiovascular disease. Being overweight or obese. Sedentary lifestyle. Nonwhite ancestry. Previously identified impaired glucose tolerance, impaired fasting glucose, and/or metabolic syndrome. Years from . diagnosis. 0. 5. -10. -5. 10. 15. Pre-diabetes. Onset. Diagnosis. Insulin secretion. Insulin “efficiency”. Ramlo-Halsted BA, Edelman SV. . Prim Care. . 1999;26:771-789 Nathan DM. . N Engl J Med. . Clinical Presentation of Type 2 Diabetes 1 Age ≥45 years Family history of T2D or cardiovascular disease Overweight or obese Sedentary lifestyle Non-Caucasian ancestry Previously identified IGT, IFG, and/or metabolic syndrome Type 2 Diabetes. High blood glucose. Insulin secretion from pancreas. ↑ Glucose absorption by muscle. Low blood glucose. Eat. Analyzed genome sequence of Steve Quake. Rare protein altering SNPs . But usually do not know what the gene does, so difficult to know if the mutation is causing a trait.. Farhad. . Hosseinpanah. . Obesity Research Center. Research Institute for Endocrine sciences. Shahid. . Beheshti. University of medical sciences. Jan . 11, . 2014. Tehran. Agenda. Overview of classification. Definition. Type 1 Diabetes. : This refers to a genetically based condition in which the cells in the pancreas that normally produce a hormone called “Insulin” stop functioning. This often appears in childhood or early adolescence. The only treatment for Type 1 Diabetes is insulin replacement (by pump or injection). Without adequate supplementary insulin, blood sugar levels dramatically increase and glucose “spills over” into the urine.. 01/12/2019. 1. 2. How this lecture will work. Overview. of topics (prioritised and simplified). Key, important points are written on the slides. Everything I say, including some extra details (that you almost defo don’t need), will be in the notes at the bottom - no need to make your own notes!. www.DiabetesEd.net. Beverly Dyck Thomassian, RN, MPH, BC-ADM, CDE. President, Diabetes Education Services. Lecture Objectives. . Discuss the current impact of diabetes. . Describe the pathway of pathophysiological defects associated with the development of diabetes. Type 1 Diabetes: Before and After Insulin. 1. . The Case for Serendipity. Available at: http://www.mc.vanderbilt.edu/lens/article/?id=221&pg=999. Accessed April 6, 2010.. 2. . Westman. et al. . Perspectives in Biology and Medicine. Vascular Tutorial (SET 1 and 2). 9 July 2020. Clinical Scenario 1. You review a 68 . yo. diabetic man in the outpatient clinic. He has a discharging sinus overlying his previously amputated third metatarsal head for the past two weeks. At that time (. Download PDF The Diabetes Loophole™ eBook by Reed Wilson - A detailed program aimed at helping you understand and address your body\'s requirements when experiencing diabetes symptoms.