Connect Learn Get Help The CTSI helps research teams work faster and better NCATS Transition 12232011 NCATS formed NCRR disbanded NCATS Purpose advance translational sciences by ID: 718575
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Slide1
Programs
September
2014Slide2
Connect
Learn
Get Help
The
CTSI
helps research
teams work
faster and better.Slide3
NCATS Transition
12/23/2011: NCATS formed; NCRR disbanded
NCATS Purpose
:
advance translational sciences bycoordinating and developing resources that leverage basic research in support of translational science; and developing partnerships and working cooperatively to foster synergy in ways that do not create duplication, redundancy, and competition with industry activities.
Leadership
Interim Director Tom
Insel
(Director of NIMH)
Chris Austin named as Director Sep 2012
Divisions of Preclinical Innovation and Clinical Innovation
had
interim
directors, Petra Kaufmann now Clinical Innovation DirectorSlide4
IOM Report – released 6/25/2013
Suggested vision:
A
“tightly integrated network that works collectively to enhance the transit of therapeutics, diagnostics, and preventive interventions along the development pipeline; disseminate innovative translational research methods and best practices; and provide leadership in informatics standards and policy development to promote shared resources
.”Recommendations (roughly in order of prominence):NCATS should take a more active leadership role as the principal party in cooperative agreementsGreatly
streamline
committee structure
The consortium should work more
cohesively
together and with external partners toward
carefully chosen strategic goals
Establish a cross-consortium “Innovation Fund”
Tighten up the evaluation program
CTSAs should be allowed more freedom to
capitalize on institutional strengths
CTSAs should concentrate efforts toward innovative education programs
CTSAs should continue to lead efforts in child health researchSlide5
Deconstruction of CTSA ConsortiumSlide6
NCATS Response to the IOM Report
NCATS Advisory Council Working Group on the IOM Report: The CTSA
Program May 2014
Workforce Development-Goal: The translational science workforce has the skills and knowledge necessary to advance translation of discoveries.
Collaboration/Engagement-Goal: Stakeholders are engaged in collaborations to advance translation. Integration-Goal: Translational science is integrated across its multiple phases and disciplines within complex populations and across the individual lifespan. Methods/Processes-Goal: The scientific study of the process of conducting translational science itself enables significant advances in translation.Slide7
Project DevelopmentSlide8
Project DevelopmentSlide9
Targeted Outcomes-UR CTSI Goals-
Clinical and translational research
education
programs produce skilled multidisciplinary research team members
Local, regional and national partnerships support and enhance clinical and translational scienceResearchers and research teams advance clinical and translational scienceClinical and translational research and supporting services are organized within a URMC academic homeA diverse spectrum of community members and organizations are engaged in the research processSlide10
Six Program Areas and UnderpinningsSlide11
Clinical and translational research
education
programs produce skilled multidisciplinary research team
membersSlide12
KL2 Career Development Program
Institutional K-award program
2 years, 75% effort
Salary support
S
ome support for other costs
Research project costs
Travel
Competitive application process
RFA released in July
Applications due ~ October
Awards announced ~ March
Two or three awards each yearSlide13
TL1
Predoctoral
Training Program
Institutional training grant linked to CTSA awardThree types of trainees
Academic Research Track for medical students (year-out program)PhD students in the Translational Biomedical Sciences ProgramMD/PhD students with an interest in translational scienceEach trainee receives a stipend and may receive some support for other costs10 trainees per yearMentors and trainees supported by CTSI Mentor Development CoreSlide14
PhD - Translational Biomedical Science
One of the first of its kind anywhere
Goal: prepare
individuals for academic and clinical careers involving the translation of basic biomedical research into clinical strategies to improve
healthRequired and elective coursework in diverse disciplinesEpidemiologyBiostatisticsMicrobiology
Immunology
Neuroscience
Pharmacology
Biochemistry
Physiology
And more…
Skill-building workshops and seminars
Research rotations (3 in first year) leading to selection of thesis topicSlide15
TL1
Predoctoral
Training Program
Academic Research Track1 year of supportMedical students apply in December and are selected in February
OptionsPursue MPH or other research-related masters’ degreeGain hands-on experience in a lab or research centerPhD-TBS studentsMulti-year support is possibleMD/PhD studentsMulti-year support is possibleSlide16
Mentor-Protégé Curriculum
At beginning of program year, protégés develop a Research Career Development Plan with their mentors
Mentoring workshops for mentors and protégés
Mentor group meeting
Protégé group meetingFall – a member of the Core meets with each protégéSpring – meeting with mentor-protégé dyadSlide17
Other Education Programs
Research Masters’ Degrees (provided by Dept. of Public Health Sciences)
MS – Translational Research
MS – Clinical Investigation
MPHNon-degree programsAcademic Core Curriculum - fellows and residents – year-long program, weekly meetingsJunior Faculty Academic Core Curriculum – one-week intensive courseSkill-building trainingOnline training in Comparative Effectiveness ResearchOnline training in FDA regulatory fundamentals
eRecord
for research
REDCap
i2b2
Annual Scientific SymposiumSlide18
Local, regional and national
partnerships
support and enhance clinical and translational science
Researchers and research teams advance clinical and translational
scienceSlide19
CTSI Research Collaboration & Services
Web-hosted information for easy reference
http://www.urmc.rochester.edu/ctsi/research-help
/
Find a range of resources and services to support each stage of research development and operationsResearch Help Desk ResearchHelp@urmc.rochester.eduFunctions as an information hub, supporting research teamsQuestions AnsweredResources IdentifiedSupport for study designMentors, collaborators and a range of institutional services
Shared resources to include in research plan
Guidance and assistance to navigate regulations and policiesSlide20
Voucher Program
To request a voucher
:
http://www.urmc.rochester.edu/ctsi/funding/voucher-system.cfmSlide21
Voucher Funding by Beneficiary ($000s)
Total = $240K since 5/2011Slide22
CTSI Project Funding Programs
Pilot Studies
Goal: facilitate new research and future project funding
1 year, $50,000
Trainee PilotsGoal: support trainee research1 year, $25,000UNYTE PilotsGoal: stimulate new cross-institutional collaborations1 year, $50,000, two or more UNYTE institutionsNovel Biostatistical and Epidemiologic MethodsGoal: stimulate new methods to improve validity, accuracy, scope or
speed
2 years, $20,000
Incubator Program
Goal
: accelerate innovative scientific discovery
leading
to new
research
programs
2 years, $125,000, two or more linked projectsSlide23
Pilot Funding by Department ($000s)Slide24
Clinical and translational research and supporting services are organized within a URMC
academic homeSlide25
Clinical Research Center
The CRC provides support for patient-oriented research:
Welcoming In- and outpatient facilities located within the Medical Center (G-5035) and in the Saunders Research Building (1.302)
Experienced assistance in Research Nursing,
Bionutrition, and Clinical Research CoordinationThe Center accommodates pediatric to adult research subjects.Access to the Center requires a short application and IRB approval.Modest fees are charged for services.Slide26
Expanding the reach and efficiency of clinical trials through technology
21
st
century technology and methodology should expand the availability of clinical research Clinical trials of new interventions (drugs, devices) will likely benefit the most from these new methodsUsing remote access (things like Skype) will permit research participants to be seen at home
Using remote data sensing (like via smart phones) will simplify getting informationBetter planning of studies will allow them to be smaller and more efficient Slide27
A diverse spectrum of
community
members and organizations are engaged in the research processSlide28
Improving the health of our community(s)
Healthcare delivery will change, driven by ACA and financial forces
URMC is committed to its Community mission
Health should improve as
healthcare changesWe need to measure what is of most importance to the health of the community and target change in healthcare to the community needsThe CTSI wants to be sure that the community’s needs for healthcare change, and measuring the impacts on community health are a URMC priorityWe need to organize how that input is structured so that it is consistently heard and acted uponSlide29
National CTSA Directions
Revamped NCATS organization- P Kaufmann
National Steering Committee setting priorities
Site supplements to lead national joint effortsFuture areas of focus uncertain still- recent RFA has substantial changes especially for CRC like structures and pilot funding
Team science essentialSlide30
For more information…
www.urmc.rochester.edu/ctsi
http://urctsi.wordpress.com
/
http://
www.linkedin.com/groups/University-Rochester-CTSI-4334207?trk=myg_ugrp_ovr
http://
www.youtube.com/user/URCTSI/featured
https://twitter.com/#!/
ur_ctsi
http://
www.flickr.com/people/urctsi
Web
http://us6.campaign-archive1.com/home/?
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