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Programs September  2014 Programs September  2014

Programs September 2014 - PowerPoint Presentation

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Programs September 2014 - PPT Presentation

Connect Learn Get Help The CTSI helps research teams work faster and better NCATS Transition 12232011 NCATS formed NCRR disbanded NCATS Purpose advance translational sciences by ID: 718575

translational research program clinical research translational clinical program year support ctsi development science urmc ncats goal programs community http

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Slide1

Programs

September

2014Slide2

Connect

Learn

Get Help

The

CTSI

helps research

teams work

faster and better.Slide3

NCATS Transition

12/23/2011: NCATS formed; NCRR disbanded

NCATS Purpose

:

advance translational sciences bycoordinating and developing resources that leverage basic research in support of translational science; and developing partnerships and working cooperatively to foster synergy in ways that do not create duplication, redundancy, and competition with industry activities.

Leadership

Interim Director Tom

Insel

(Director of NIMH)

Chris Austin named as Director Sep 2012

Divisions of Preclinical Innovation and Clinical Innovation

had

interim

directors, Petra Kaufmann now Clinical Innovation DirectorSlide4

IOM Report – released 6/25/2013

Suggested vision:

A

“tightly integrated network that works collectively to enhance the transit of therapeutics, diagnostics, and preventive interventions along the development pipeline; disseminate innovative translational research methods and best practices; and provide leadership in informatics standards and policy development to promote shared resources

.”Recommendations (roughly in order of prominence):NCATS should take a more active leadership role as the principal party in cooperative agreementsGreatly

streamline

committee structure

The consortium should work more

cohesively

together and with external partners toward

carefully chosen strategic goals

Establish a cross-consortium “Innovation Fund”

Tighten up the evaluation program

CTSAs should be allowed more freedom to

capitalize on institutional strengths

CTSAs should concentrate efforts toward innovative education programs

CTSAs should continue to lead efforts in child health researchSlide5

Deconstruction of CTSA ConsortiumSlide6

NCATS Response to the IOM Report

NCATS Advisory Council Working Group on the IOM Report: The CTSA

Program May 2014

Workforce Development-Goal: The translational science workforce has the skills and knowledge necessary to advance translation of discoveries.

Collaboration/Engagement-Goal: Stakeholders are engaged in collaborations to advance translation. Integration-Goal: Translational science is integrated across its multiple phases and disciplines within complex populations and across the individual lifespan. Methods/Processes-Goal: The scientific study of the process of conducting translational science itself enables significant advances in translation.Slide7

Project DevelopmentSlide8

Project DevelopmentSlide9

Targeted Outcomes-UR CTSI Goals-

Clinical and translational research

education

programs produce skilled multidisciplinary research team members

Local, regional and national partnerships support and enhance clinical and translational scienceResearchers and research teams advance clinical and translational scienceClinical and translational research and supporting services are organized within a URMC academic homeA diverse spectrum of community members and organizations are engaged in the research processSlide10

Six Program Areas and UnderpinningsSlide11

Clinical and translational research

education

programs produce skilled multidisciplinary research team

membersSlide12

KL2 Career Development Program

Institutional K-award program

2 years, 75% effort

Salary support

S

ome support for other costs

Research project costs

Travel

Competitive application process

RFA released in July

Applications due ~ October

Awards announced ~ March

Two or three awards each yearSlide13

TL1

Predoctoral

Training Program

Institutional training grant linked to CTSA awardThree types of trainees

Academic Research Track for medical students (year-out program)PhD students in the Translational Biomedical Sciences ProgramMD/PhD students with an interest in translational scienceEach trainee receives a stipend and may receive some support for other costs10 trainees per yearMentors and trainees supported by CTSI Mentor Development CoreSlide14

PhD - Translational Biomedical Science

One of the first of its kind anywhere

Goal: prepare

individuals for academic and clinical careers involving the translation of basic biomedical research into clinical strategies to improve

healthRequired and elective coursework in diverse disciplinesEpidemiologyBiostatisticsMicrobiology

Immunology

Neuroscience

Pharmacology

Biochemistry

Physiology

And more…

Skill-building workshops and seminars

Research rotations (3 in first year) leading to selection of thesis topicSlide15

TL1

Predoctoral

Training Program

Academic Research Track1 year of supportMedical students apply in December and are selected in February

OptionsPursue MPH or other research-related masters’ degreeGain hands-on experience in a lab or research centerPhD-TBS studentsMulti-year support is possibleMD/PhD studentsMulti-year support is possibleSlide16

Mentor-Protégé Curriculum

At beginning of program year, protégés develop a Research Career Development Plan with their mentors

Mentoring workshops for mentors and protégés

Mentor group meeting

Protégé group meetingFall – a member of the Core meets with each protégéSpring – meeting with mentor-protégé dyadSlide17

Other Education Programs

Research Masters’ Degrees (provided by Dept. of Public Health Sciences)

MS – Translational Research

MS – Clinical Investigation

MPHNon-degree programsAcademic Core Curriculum - fellows and residents – year-long program, weekly meetingsJunior Faculty Academic Core Curriculum – one-week intensive courseSkill-building trainingOnline training in Comparative Effectiveness ResearchOnline training in FDA regulatory fundamentals

eRecord

for research

REDCap

i2b2

Annual Scientific SymposiumSlide18

Local, regional and national

partnerships

support and enhance clinical and translational science

Researchers and research teams advance clinical and translational

scienceSlide19

CTSI Research Collaboration & Services

Web-hosted information for easy reference

http://www.urmc.rochester.edu/ctsi/research-help

/

Find a range of resources and services to support each stage of research development and operationsResearch Help Desk ResearchHelp@urmc.rochester.eduFunctions as an information hub, supporting research teamsQuestions AnsweredResources IdentifiedSupport for study designMentors, collaborators and a range of institutional services

Shared resources to include in research plan

Guidance and assistance to navigate regulations and policiesSlide20

Voucher Program

To request a voucher

:

http://www.urmc.rochester.edu/ctsi/funding/voucher-system.cfmSlide21

Voucher Funding by Beneficiary ($000s)

Total = $240K since 5/2011Slide22

CTSI Project Funding Programs

Pilot Studies

Goal: facilitate new research and future project funding

1 year, $50,000

Trainee PilotsGoal: support trainee research1 year, $25,000UNYTE PilotsGoal: stimulate new cross-institutional collaborations1 year, $50,000, two or more UNYTE institutionsNovel Biostatistical and Epidemiologic MethodsGoal: stimulate new methods to improve validity, accuracy, scope or

speed

2 years, $20,000

Incubator Program

Goal

: accelerate innovative scientific discovery

leading

to new

research

programs

2 years, $125,000, two or more linked projectsSlide23

Pilot Funding by Department ($000s)Slide24

Clinical and translational research and supporting services are organized within a URMC

academic homeSlide25

Clinical Research Center

The CRC provides support for patient-oriented research:

Welcoming In- and outpatient facilities located within the Medical Center (G-5035) and in the Saunders Research Building (1.302)

Experienced assistance in Research Nursing,

Bionutrition, and Clinical Research CoordinationThe Center accommodates pediatric to adult research subjects.Access to the Center requires a short application and IRB approval.Modest fees are charged for services.Slide26

Expanding the reach and efficiency of clinical trials through technology

21

st

century technology and methodology should expand the availability of clinical research Clinical trials of new interventions (drugs, devices) will likely benefit the most from these new methodsUsing remote access (things like Skype) will permit research participants to be seen at home

Using remote data sensing (like via smart phones) will simplify getting informationBetter planning of studies will allow them to be smaller and more efficient Slide27

A diverse spectrum of

community

members and organizations are engaged in the research processSlide28

Improving the health of our community(s)

Healthcare delivery will change, driven by ACA and financial forces

URMC is committed to its Community mission

Health should improve as

healthcare changesWe need to measure what is of most importance to the health of the community and target change in healthcare to the community needsThe CTSI wants to be sure that the community’s needs for healthcare change, and measuring the impacts on community health are a URMC priorityWe need to organize how that input is structured so that it is consistently heard and acted uponSlide29

National CTSA Directions

Revamped NCATS organization- P Kaufmann

National Steering Committee setting priorities

Site supplements to lead national joint effortsFuture areas of focus uncertain still- recent RFA has substantial changes especially for CRC like structures and pilot funding

Team science essentialSlide30

For more information…

www.urmc.rochester.edu/ctsi

http://urctsi.wordpress.com

/

http://

www.linkedin.com/groups/University-Rochester-CTSI-4334207?trk=myg_ugrp_ovr

http://

www.youtube.com/user/URCTSI/featured

https://twitter.com/#!/

ur_ctsi

http://

www.flickr.com/people/urctsi

Web

http://us6.campaign-archive1.com/home/?

u=85ca914d3653b31ff7ca776b9&id=65bec3c724