Memantine and IMRT Planning for Hippocampus Sparing in Patients Receiving Whole Brain Radiotherapy for Brain Metastases Alexander Slade PhD and Sinisa Stanic MD Carle Cancer Center and University of Illinois College of Medicine at UrbanaChampaign ID: 440891
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The Impact of RTOG 0614 and RTOG 0933 in Routine Clinical Practice: The US Survey of Utilization of Memantine and IMRT Planning for Hippocampus Sparing in Patients Receiving Whole Brain Radiotherapy for Brain Metastases
Alexander Slade, PhD and Sinisa Stanic, MDCarle Cancer Center and University of Illinois College of Medicine at Urbana-ChampaignUrbana, ILSlide2
Use of Memantine in WBRT Patients
Patients have poor KPS and limited life expectancy, without enough time to see the benefit (50%)
Results of RTOG 0614 are not impressive
(23%)
Cost prohibitive
(14%)
Others: not aware of the study, not covered by insurance, no interest in study, already use Memantine.
Primary Reasons for Not Using Memantine
Slade and Stanic, ASTRO 2014Slide3
Consideration of IMRT Planning for Hippocampus Sparing
Reasons for Not
C
onsidering
IMRT Planning for Hippocampus Sparing
Slade and Stanic, ASTRO 2014Slide4
Is Further Validation of IMRT
Planning for Hippocampus Sparing in a Phase III Clinical Trial Warranted?
Slade and Stanic, ASTRO 2014
Is Further Validation of
Memantine
in New Clinical Trial Employing WBRT Warranted? Slide5
ConclusionsThe majority of surveyed radiation oncologists in the US do not use Memantine, or IMRT planning for hippocampus sparing in patients receiving WBRT at this time.
Further validation of the hippocampus sparing concept in a phase III trial was felt to be necessary before adopting it in routine clinical practice.
Slade and Stanic, ASTRO 2014