a NSG Rosiglitazone maleate treated mouse b NSG mouse 1 year old c hSCF mouse hSCF cytokine 1 year old NSG SGM3 mouse IL3 hSCF GMSCF 1 year old Extended data Control NSG mouse ID: 1041887
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1. Castrated NSG mouse Control NSG mousea.NSG Rosiglitazone maleate treated mouseb.NSG mouse -1 year oldc.hSCF mouse (hSCF cytokine) -1 year oldNSG- SGM3 mouse (IL-3, hSCF, G-MSCF) -1 year oldExtended dataControl NSG mouseFigure 1s
2. CastrationNSG mice Following 1 monthHuman BM was injectedNBM NSG miceFollowing 1 monthBM was injectedEngraftment analysisa.Following 1 weekHuman AML/ DNMT3A+VAV+ derived BM Was injectedFollowing 1 weekHuman AML/ DNMT3A+VAV+ derived BM Was injectedLow doseirradiationNSG miceNBM NSG miceCastratedNSG mice NBM NSG miceFigure 2s
3. a.b.f.c.primarysecondaryd.primarysecondarye.2 month old miceOne year old miceFigure 3s
4. secondarya.b.Primary2 month old mice1 year old miceFigure 4s
5. a.b.c.d.e.f.Figure 5s
6. a.b.UnselectedDNMT3A Mut + FBMDNMT3A WT + FBMFigure 6s
7. a.b.c.INFA Score*******INFA Score wo INFG genes****INFG Score wo INFA genes********d.**NSNSTNFA Score wo INFG genesFigure 7s
8. DNMT3AMuta.b.c.DNMT3AWTd.Figure 8s