BREAKDOWN OF HIV RESEARCH BASIC SCIENCE Seeks the f undamental understanding of the biological chemical and physical nature of HIV CLINICAL SCIENCE Seeks the understanding of the prevention treatment andor the diagnosis of HIV infection in humans ID: 915089
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Slide1
Introduction to Basic Science of HIV/AIDS
Slide2BREAKDOWN OF HIV RESEARCH
BASIC
SCIENCE
Seeks the
f
undamental understanding of the biological, chemical, and physical nature of HIV.
CLINICAL SCIENCE
Seeks the understanding of the prevention, treatment, and/or the diagnosis of HIV infection in humans.
SOCIAL/BEHAVIORAL SCIENCE
Seeks the systematic analysis and investigation of human
behavior in the context of HIV.
Slide3Relationship of the sciences
Translational
Science
Slide4Don’
t’ be afraid to ask questions or have us slow down
Slide5Scientists are people too…
Slide6A lot of things seem obvious…
Slide7OUTLINE OF BASIC SCIENCE
Module 1.1 Natural History of HIV
Data Interpretation and Biostatistics
HIV Structure, Lifecycle, and Replication
Overview of the Human Immune System
Origins of HIV
Immune Responses to HIV
Pathogenesis of HIV Disease and Markers of Progression
Immune Reconstitution
Module 1.2 HIV Basic Science
Introduction to Basic Sciences
Model Systems to Study HIV
Major Basic Science Discoveries in HIV
Current HIV Basic Science Research Topics
HIV Cure
Translation Science – Bench to Bedside to Community
Future Directions in HIV Basic Science Research
Slide8History of HIV from the Basic Science Perspective
1940’s: Evidence of the first infections of humans with HIV (discovered in the 00’s)
1981: First clinical report of AIDS (UCLA)
1983: Discovery of HIV
1985: AZT, first antiretroviral drug
1996: Effective combination therapy (HAART)
2009: First reported “cure” of HIV infection
Slide9History of HIV from the Basic Science Perspective
(Contributions of Basic Science)
1940’s: Evidence of the first infections of humans with HIV
Identification and analysis of virus in frozen blood
samples
1981: First Clinical report of AIDS (UCLA)
Identified CD4 T cell loss
1983: Discovery of HIV
HIV was grown in the lab from a patient’s blood
1985: AZT first antiretroviral drug
Addition of AZT to virus stopped its growth in the lab
1996: Effective combination therapy (HAART)
Development of new classes of drugs were due to greater understanding of the viruses structure and replication
2009: First reported “cure” of HIV infection
Identification of people who were not susceptible to infection due to lack of expression of an HIV receptor
Slide10What to look Out for:
Basic Science
Understanding of how the virus replicates
Understanding of how antiretroviral drugs work
U
nderstanding of the human immune system and how it is important in HIV infection
Understanding of how HIV causes disease
Understanding of how passionate HIV researchers are in finding a cure and what these approaches may be.
Slide11What basic scientists do needs to be conveyed to find a cure for HIV disease
Understanding basic science aspects of HIV infection helps to communicate new research
findings, better treatment options, and hope to your constituencies.