PPT-Lab. 4 granulation method of tableting

Suhair Alawaad BSc Pharm Uni of Basra College of Pharmacy MSc IPSci Brighton University School of Pharmacy and Biomedical Sciences UK 1 find study materials on link googlKBOm0R. Comparing Granulation Methods Figure 3: Fluid bed top spray granulator GRANULATIONSingle Pot - A mixer/granulator that dries granules in the same equipment without discharging is commonly called a Sin :. فهد جلعود سيف القحطاني. رقم المنسوب :. 4350182. التخصص. : . معيد . ب. كلية الصيدلة . – قسم الصيدلانيات. استخدام الحاسب لتقديم و شرح محاضرة عن طريق برنامج . TABLET MANUFACTURE . FORMULATION AND PROCESSING. Why are tablets the most popular dosage form for medicines?. Tablet compression. What is a ‘good’ tablet?. Tablet constituents. Direct Compression. Intermediate batch scale . Manufacture. Objectives of scale up. Formulation related: Identification & control of critical components, other variables.. Equipment related: Identification & control of critical parameters & operations. Dry granulation. Granulation. is the process in which the . primary powder particles . are made to . adhere to form large multi –entities . called granules.. Primary reasons for granulation: . Secondary reasons for granulation. The wet granulation technique uses the same preparatory and finishing steps of direct compression and dry granulation (. dry. . screening and mixing. ); it also involve additional steps of . wet massing, wet screening and drying.. Dry methods. Direct compression. Dry granulation. Wet methods. Wet granulation. Advantages. - Economy. - Machine: fewer manufacturing steps and pieces of equipment. - Labor: reduce labor costs. - Less process validation. The process has been developed including Quality by Design (. QbD. ) Elements. . The team utilized structured, multivariate experimentation (DOE). The design is a response surface custom experiment with 21 runs. In order to optimize this process and maximize desirability for formulations comprising of certain spray-dried amorphous dispersions, we recommend using:. Mannitol. as a filler and a ratio of brittle: ductile components . Lab 3 t To prevent segregation. To improve flow properties of the mix. To improve compaction characteristics of the mix. Dry granulation Granulation is the process in which the primary powder partic Wet Granulation The wet granulation technique uses the same preparatory and finishing steps of direct compression and dry granulation ( dry screening and mixing ) ; it also involve additional steps of MCC Starch Lactose Superdisintegants Wet granulation of milled Wet granulation of milled lactose Summary Lactose is commonly wet granulated with microcrystalline cellulose in the preparation of pharma IJRPC 2017, 7( 3 ), 2 3 2 - 2 3 8 et al. ISSN: 2231  2781 232 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com TO STUDY AND UNDERSTAND THE PROCESS OF wet granulation method . Presented by . Assistant Lecturer: Aula Jawad. Steps of Wet Granulation. weighing and mixing of the ingredients. Specified amounts of active ingredients, fillers, and disintegrating agents are mixed until a homogeneous mixture is formed.