MATERNAL SERUM ALPHAFETOPROTEIN FETAL OUTCOME - PDF document

MATERNAL SERUM ALPHA-FETOPROTEIN FETAL OUTCOME and May 1991, 29 women with early second-trimester the prenatal Gestational age varied between 20 weeks real-time assessment fetal size placental localization, and amniotic fluid volume. A linear real-time system the largest pocket of these sera stored until assay. a polyclonal assay (ELISA) definition of raised 97th centile described previously with a three-stage monoclonal antibody weights were related reference weight for the rank sum was applied tract. Distribution frequencies of Fisher exact test, of fetal were related post-mortem examination fetuses were (cases 25 the fetus displayed undetected m

oderate growth retardation between 39 group without between 47 fetal urinary malformations. This difference in significant (Wilcoxon of 26 cent), seven of which carried a fetus urinary tract two fetuses In the two carried a urinary tract SERUM ALPHA-FETOPROTEIN nine women with fetal Classification of cystic kidneys (types Case gestation Fetal outcome bilateral renal Enlarged urinary Multicystic kidneys, Enlarged urinary bladder, Enlarged urinary agenesis (left), Bilateral renal bilateral renal urethral obstruction, cystic kidneys type kidneys type urethral hypoplasia, bladder, hydronephrosis, agenesis (left), ulnar deviation of bilateral renal hypo

plastic ureter (right), renal agenesis (left) bilateral renal 1)mat. Maternal lpter-1 lq21::8ql2-.8qter)mat. incidence of urinary tract with raised levels is exact test, pg/l (median without fetal pg/1) in the nine women with significant (Wilcoxon this gender (binomial statistics, fetal outcome with early oligohydramnios without fetal malformations Fetal outcome no necropsy intrauterine growth retardation; death post-partum; =intrauterine death. of whom displayed a tract anomaly. previous pregnancy. these women (case had also second-trimester oligohydramnios other two there had oligohydramnios. In the women without fetal anomaly, a previous preg- i

nstances, a delivered (cases were measured per cent). seven of these nine women, congenital malformations of the fetal urinary tract, resulting in fetal anuria or Fetal anuria predisposing factors for subsequent early second-trimester Second-trimester oligohydramnios in only two of the nine fetal diuresis major source of the SERUM ALPHA-FETOPROTEIN 17 18 Open circles/squares female/male fetuses congenital malformations; closed signs, levels in the presence of a sources: fetal urine, secretions from the fetal respiratory tracts, from the in the trimester of yolk sac, Fetal urine would have little effect the non-Concanavalin pool of compartment cont

ributes percentage of in median without fetal anomalies the lack of A reduced fetal gestational age fetuses, all without fetal intrauterine growth retardation 0 0 associated with second-trimester to the compartment (Hackett Damage to the fetal membranes might occur for feto-maternal normal situation in early second-trimester compartment-barrier model, passive process concentration gradients from the fetus mother, from the amniotic compartment, and the amniotic across various membranes the absence of barrier (infinite resistance in lower compartment(s). The absence of urinary tract barrier the amniotic growth retardation, the amniotic subsequent bre

akdown of the barrier the amniotic the mother (fetal membranes). Mechanical damage of this barrier has suggested in early second-trimester oligohydramnios following intrauterine instrumentation model for feto-maternal transfer. On of gestation onwards, after fusion of decidua on the early second-trimester oligohydramnios. barrier between the fetus (fetal skin; tracts; umbilical and part plate occupied and mother and part not occupied between yolk (extraembryonic coelomic space) mother (chorionic plate before fusion of amnion and chorion) the present in the absence fetal membranes origin may be less damage than those of has to further substantiated.

Early second-trimester oligohydramnios Our data recurrence risk early second-trimester fetuses with urinary tract abnormalities. of a in early second-trimester oligohydramnios urinary tract pathology. for preparing support and the manuscript. Taubert, H.D. ersten Schwangerschaftshalfte, B.K., Nelson, L.H. maternal serum early pregnancy. G.A., Nicolaides, K.H., in severe second trimester R.B., Nyberg, D.A., Mack, L.A., Fitzsimmons, Sonography of placental abnormalities and oligohydramnios in women with elevated growth, the significance of prenatal care, sampling in second trimester feto-maternal transfusions Prenat. Diagn., J.R., Marrink, in second

trimester oligohydramnios, in press. (1990). Mendelian inheritance Autosomal Dominant, X-Linked Phenotypes, ed., Baltimore: John Hopkins Marrink, J., Vries, E.G.E., Schraffordt Koops, fetoprotein-lectin binding a marker V.L., Lingley, Cefalo, R.C. with oligohydramnios: ultrasound evaluation and outcome, Seppala, M. in cancer fetal development, E., Engvall, Pekkala, A., Seppala, M. (1978). Developmental changes moiety of the soluble pregnancy. Methodological clinical studies, Kingdom Collaborative in Relation Neural Tube Maternal serum-alpha-fetoprotein measurement in screening for early pregnancy, Volpel, M.-C., Cystic kidneys, genetics, pathologic