Chimney sweeps cancer of the scrotum Potts disease vertebral tuberculosis John Hunter 1728 1793 Papers at the Royal Society on experimental pathology including the use of a microscope ID: 1045079
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1. Percivall Pott1714 – 1788 Chimney sweeps cancer of the scrotum Pott’s disease – vertebral tuberculosis
2. John Hunter1728 – 1793 Papers at the Royal Society on experimental pathology, including the use of a microscopeDescribed inflammationHunterian Museum, Royal College of Surgeons, London
3. First Systematic Textbook of PathologyMatthew Baillie – 1761 – 1823 Nephew of John HunterThe Morbid Anatomy of Some of the Most Important Parts of the Human BodyMicroscopic pathology atlasPhysician of King George III
4. Thomas Hodgkin1798 – 1866 On Some Morbid Appearances of the Absorbent Glands and the Spleen“Lister’s compound microscope might lead to useful discoveries in the future.”
5. Joseph Recamier – 1774 – 1852 – metastasis Richard Bright – 1789 – 1858 – Kidney diseaseThomas Addison – 1793 – 1860 – Pernicious anemia
6. Cell TheoryRobert Hooke – 1635 – 1703 – cellMatthias Jacob Schleiden – 1804 – 1881 – botanist Theodor Schwann – 1810 – 1882 – zoologist
7. Cell TheoryJohannes Peter Müller1801 – 1858BerlinFather of medical microscopyMicroscopic criteria for benign and malignant tumorsÜber den Feinern Bau und die Formen der Krankhaften Geschwülste – On the Finer Structure and Form of Morbid Tumors
8. Cell TheoryRudolph Virchow1821 – 1902 The greatest figure in the history of PathologyDie Cellularpathologie“Omnis cellula e cellula” – all cells from cells
9. Herman Lebert – 1831 – 1878 Microscopic atlas
10. 1850sPathology developed as a separate specialtyMedical schools, Professors of PathologyMicroscope, diagnostic histopathology, neoplasiaFrance – laboratoriesGermany – universities
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12. MicroscopeFresh tissue, cut by hand, unstainedFormaldehyde fixation – Isaac Blum – 1833 – 1903 Paraffin embedding – Edwin Klebs – 1834 – 1913 Microtome – Minot – 1852 – 1914 Biological stainsHematoxalin – Franz BöhmerPaul Ehrlich – 1854 – 1915
13. AnaplasiaDavid Von Hansemann1858 – 1920
14. Grading, Carcinoma in SituAlbert Compton Broders1885 – 1964 Mayo Clinic
15. StagingCuthbert Esquire Dukes1890 – 1977 St. Mark’s Hospital, London
16. Pap SmearGeorge Papanicolaou – 1883 – 1962 January, 1928 – New Cancer Diagnosis – Betterment Conference Battle Creek Michigan1941 – The Diagnostic Value of Vaginal Smears in Carcinoma of the Uterus1943 – Diagnosis of Uterine Cancer by the Vaginal Smear1954 – Atlas of exfoliative Cytology