Santosh Kapuria IIT Delhi Charles Steele Stanford Sunil Puria Stanford 2 Microstructure of BM Detailed anatomy Guinea pig S Iurato 1962 Cat LM Cabazudo 1978 Gerbil Schweitzer L Lutz C Hobbs M Weaver SP 1996 ID: 542176
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Mechanics of the Unusual Basilar Membrane in Gerbil
Santosh Kapuria, IIT Delhi
Charles Steele, Stanford
Sunil Puria, StanfordSlide2
2
Microstructure of BM
Detailed anatomy
Guinea pig: S Iurato (1962)
Cat: LM Cabazudo (1978)
Gerbil: Schweitzer L, Lutz C, Hobbs M, Weaver SP (1996)
Point load measurements
Human: Békésy (1960)
Guinea pig: Gummer WA, Johnstone BM, Armstrong NJ (1981)
Miller, C (1985)
Gerbil: Olson EE, Mountain DC (1994)
Naidu, RC, Mountain DC (1998)
Emadi G, Richter CP, Dallos P (2004)Slide3
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Iurato 1962,gpSlide4
4
I- BeamSlide5
Beam with constraints
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6
Gerbil organ of Corti
Arc of BM
Edge,
et al. (1998)Slide7
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Gerbil OC (Corrales,
2006)
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8
Beam model for BMSlide9
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Arch modelSlide10
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Buckling of archSlide11
Olson and Mountain 1994
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Emadi et al. 2004
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Emadi, et al. (2004)Slide14
Point load on arch
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Pressure loading without Pillar stiffnessSlide16
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Frequency mapSlide17
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Fast4 model of OCSlide19
Gerbil 2.75 mm, 1 kHz, wavelength = 10 mm
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Gerbil 2.75, with pressure amplitudes
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Gerbil at 2.75 mm, add axial flow amplitudes
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Gerbil at 2.75 mm, add axial flow
amplitudes with viscosity22Slide23
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Gerbil at BF, add axial viscositySlide24
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Acknowledgement
Fulbright Fellowship to SK
NIH RO1 DC007910Slide25
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Close up, showing cilia and tip linksSlide26
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07/07/2011
Lubrication theory
HS
TM
IHC tip of cilium
gapTM
gapHS
qHS
qTM
pressL1
pressIS
Fluid displacement FD
FD
gapHS
gapTM
= –
pressL1– pressIS
qHS
qTM
perm
*
d/dt
Edge, et al. (1998)