By Dania blanco What is Fibrodysplasia ossificans progressiva Fibrodysplasia ossificans progressiva also known as FOP is a disorder in which muscle and connective tissue are gradually replaced by solid bone ID: 479288
Download Presentation The PPT/PDF document "Fibrodysplasia ossifacans progressiva" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Fibrodysplasia ossifacans progressiva
By Dania blancoSlide2
What is Fibrodysplasia ossificans progressiva?
Fibrodysplasia ossificans
progressiva, also known as FOP, is a disorder in which muscle and connective tissue are gradually replaced by solid bone.
In many cases, injuries can cause joints to fuse together and become permanently frozen in place.Slide3
The body “heals” the damaged area with bone instead of new muscle tissue.Slide4
Past History
In the late 17th
century, a French physician Guy Patin met a patient who was the first patient to be diagnosed with FOP.
The most famous person who was diagnosed with FOP is Harry Eastlack. His limbs got locked into place once the tissue turned into bone. He was so ossified, he could only move his lips. He lived up to be 40 years old before he died of his disease.Slide5
Since he donated his body to science, his skeleton was displayed in a museum in Pennsylvania.Slide6
Signs and symptoms
Tumor like swelling in the shoulders and back.
Malformation of a newborns big toe.
When the body starts to generate new bone, the patient usually experiences a painful flare-up.Slide7
Mode of transmission
The only way to get FOP is through genetics. It is rare for an offspring to get FOP if their parents have it. Slide8
Current state of disease
1 in 2 million people are born with this disease. 1,000 people suffer from this disease worldwide.
It is extremely rare to be born with this disease.
Because of the lack of knowledge of FOP among doctors, the rate of misdiagnosed of the disease is estimated at 80 percent or higher.
It is mostly misdiagnosed for cancerSlide9
Past treatments
In the past they would attempt to remove the excess bone surgically.B
ut that only resulted in more bone formation.Slide10
Current Treatments
There is no known cure for FOPMedications are available to help ease pain and inflammation.Slide11
Future treatments and outlook for disease
A drug is being developed that may help to control bone growth.
There is only one doctor,
M.D Frederick S. Kaplan, that is looking for a cure for this disease.