PDF-EEA1 early endosomes
Rab25
GIPC1
Myo6
APPL
Late endosomeslysosomes
Degradation
Rab5
CLIC3
CLIC3
Rab4
Rab11
Inactive and bent
conformation
Primed
2
3
Active and extended
conformation
A
B
Rab5
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