PPT-Glomerular diseases- 2 1

Glomerular diseases 2 Diseases leading to Nephritic syndrome 2 3 The Nephritic Syndrome Pathogenesis proliferation of the cells within the glomeruli accompanied by a leukocytic infiltrate . Dr Rebecca Martin F2. Learning objectives. Appreciate the fact that glomerular diseases fall onto a wide spectrum. Be able to define the nephritic and nephrotic syndromes. Understand the pathology of 4 key glomerular diseases which serve as archetypal examples of nephritic and nephrotic syndrome. Control of the GFR. Autoregulation (local level). Hormonal regulation (initiated by kidneys). Autonomic regulation (by sympathetic division of ANS). Glomerular Filtration. Autoregulation of the GFR . Glomerular. Filtrate. The water, waste products, salt, glucose, and other chemicals that have been filtered out of the blood at the . glomerulus. (. gloh-mer-yuh-luhs. ) are known collectively as . 2. CLINICAL MANIFESTATIONS OF RENAL DISEASES. . 1-Azotemia. . refers to an elevation of blood urea nitrogen(BUN) and creatinine levels. It is largely related to a decreased glomerular filtration rate (GFR).. Anke Banks. Anke.banks@ahs.ca. Jan. 23, 2020. Outline. Approach to the abnormal urinalysis. Hematuria. Macro. Micro. Proteinuria. Hypertension. Weird stuff. Barrter’s. . Gitelmans. Maybe RTAs. Approach to the Abnormal Urinalysis. Dr.Ghaith. Ali Jasim. . Body fluids & Renal physiology. The . intracellular. component of the body water accounts for about . 40%. of body weight.. The . extracellular. component for about . Basil Hanna. D. isorders of Renal System. In this lecture….. Diabetic . Glomerulosclerosis. Hypertensive . Glomerular. Disease . Drug Related Nephropathies . . Diabetic . Glomerulosclerosis. . 13, 43-48 (1977) Size and Structure in Diabetes Mellitus. II. Late Abnormalities J. G. Gundersen and R. r Second University Clinic of Internal Medicine and the University Institute of Pathology, Uni ecreased complement factor HDecreased complement factor IDecreased complement factor Becreased surface expression of membrane cofactor protein (MCP) in peripheral blood leukocytes by FACSerum antiCFHI v . Tubules and . interstitium. Disorders . v . Blood vessels Disorders . Figure (1) high-power light microscope of rat glomerulus, basement membrane, capillary lumen; endothelium; Ep, visceral epithelial cells (podocytes) with foot processes;, . TEXT read by the doctor is . coloured. RED. Extra notes are . coloured. maroon. Some pictures have extra information in the “notes” section so do not forget to read them. The doctor said she will mainly ask about what she reads, the skipped slides should be . The kidney plays a . major role in . controlling the volume of blood. (water) and also . controlling ion concentration and PH. . It is the major excretory organ, responsible for the . removal. of metabolic waste products from the blood..  . DIAGNOSIS. History .. Physical exam.. Investigations:. Labs.. Imaging.. Renal biopsy.. History . Onset ( sudden or gradual).. Symptoms: . edema,hematuria,proteinuria,etc. .. Family history.. Drug history.. and Nephritic Syndromes. John Higgins. Learning Objectives. M. orphology of renal injury. Mechanisms of glomerular injury and . clinicopathologic. correlations of prototype disease with a typical clinical presentation.