PPT-Fingolimod ( Gilenya ) Presented by Matthew

Brickey Tim Robinson Tom McGinnis and Katie Youmans Outline D isease Multiple Schlerosis D iscovery of FingolimodGilenya S ynthesis and lead modification Mechanism of action Pharmacology . " Therefore whoever hears these sayings of Mine, and does them, I will liken him to a wise man who built his house on the rock: and the rain descended, the floods came, and the winds blew and beat on that house; and it did not fall, for it was founded on the rock. " But everyone who hears these sayings of Mine, and does not do them, will be like a foolish man who built his house on the sand: and the rain descended, the floods came, and the winds blew and beat on that house; and it fell. And great was its fall.". Study Design. 24-month, RCT of . fingolimod. 0.5 mg and 1.25 mg vs placebo. 3 years into the study, 1.25 mg discontinued and patients placed on 0.5 mg in blinded manner . R. elapsing-remitting MS patients . " Judge not, that you be not judged. For with what judgment you judge, you will be judged; and with the measure you use, it will be measured back to you. And why do you look at the speck in your brother's eye, but do not consider the plank in your own eye? Or how can you say to your brother, " Let me remove the speck from your eye '; and look, a plank is in your own eye? . “For whoever desires to save his life will lose it, but whoever loses his life for My sake will find it.”. CHRISTIAN MARTYRDOM. PARTS OF WORSHIP. TEACHING . (DIDACHE). PREACHING . (KERYGMA). FELLOWSHIP . What Does Jesus Teach? . 1/23/2016. “. Covenant Breakers. ”. Matthew 5:27-37. Jesus directly confronts our relational sins. Adultery. Matthew 5:27. You . have heard that it was said, ‘You shall not commit adultery.. A free CD of this message will be available following the service. IT WILL ALSO be available LATER THIS WEEK. VIA cALVARYOKC.COM. The Torah (the Law) is the Old Testament standard (613 precepts). MATTHEW 5:1-16. A free CD of this message will be available following the service. IT WILL ALSO be available LATER THIS WEEK. VIA cALVARYOKC.COM. Is. 5:1-7 ~ . 1 . Now let me sing to my Well-beloved A song of my Beloved regarding His vineyard:. Matthew . 18:21-22 . 21 . Then Peter came to Jesus and asked, "Lord, how many times shall I forgive my brother when he sins against me? Up to seven times. ?“. 22 . Jesus answered, "I tell you, not seven times, but seventy-seven times. . History surrounding the book. The Law, the Prophets and the Psalms. Seed of woman (Son of virgin). Seed of Abraham. Shiloh of Judah. The Prophet. Gospel of Matthew. History surrounding the book. The Law, the Prophets and the Psalms. (. Humility. ). . Both the Apostles and the Church grew in importance. . The Savior discussed several issues relative to the church and its leaders. . The first was His concern with humility. . . 24:36-42;. 25:1-30. 14. Memory . Verse. “Because of the increase of wickedness, . the . love of most will grow cold, . but . he who stands firm to the end . . will . be saved.. Matthew 24:12-13. Matthew. AL . Ghazawi. Associated Professor. Neurologist. MRCP,FRCP UK. What is Multiple Sclerosis (MS)?. 1-. CHRONIC Autoimmune demyelination. disease of. CNS:. a- brain. b-optic nerve. c- and spinal cord. sclerosis (MS. ) . is an inflammatory disease of the central nervous system (CNS), variable in symptoms and presentation. Multiple describes the number of CNS lesions, and sclerosis refers to the demyelinated lesions, today called plaques.. CIS. RIS. CDMS. SPMS. From RIS to first relapse. Younger age. Male sex. Spinal cord lesions. Long-term disability progression. T2 and T1 lesion volume. Whole brain / GM volume changes. Cortical lesion volume / number.