PPT-POTENTIATORS: HOW DO THEY IMPACT THE FATE OF CFTR DURING BI

Author : giovanna-bartolotta | Published Date : 2017-09-30

1 Cellular Protein Chemistry Faculty of Science Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands 2 Galapagos NV Generaal De Wittelaan L11A3 2800

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POTENTIATORS: HOW DO THEY IMPACT THE FATE OF CFTR DURING BI: Transcript


1 Cellular Protein Chemistry Faculty of Science Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands 2 Galapagos NV Generaal De Wittelaan L11A3 2800 Mechelen Belgium . Macbeth. ?. How is the image above connected to today. ’. s LO?. . What does the word fate mean?. CW. 10. th. Sept.. . Fate = . something that is destined to happen, beyond a person’s control. Year 13 . Lesson 7 & 8. Tuesday, December 3. rd. , 2013.. Review Judeo-Christian View of God . Look at passages, scripture from Old and New Testament. An Eternal God. . and Omniscient God. Issues arising from these concepts. Rosa Rodriguez. What is it?. Cystic fibrosis is a hereditary disease that affects the cystic fibrosis transmembrane conductance regulator (CFTR) protein, thus its name. . Lifelong progressive disease. Tim . Vortherms*, Anne-Sophie Wesse, Arlene Manelli. *, Andrew Swensen. *. , . Ashvani . Singh*, Gert . de Wilde, Bertrand Heckmann, Steven van der Plas, Thierry Christophe, Katja Conrath, Xueqing Wang*, Chris Tse. www.glpg.com. Defects in CFTR that result in Cystic Fibrosis can be broadly categorized into three processes: translational, folding/maturation, and functional. To. address the underlying causes affecting the folding/maturation and functional properties of CFTR, two biomolecular activities are required, namely correctors to increase CFTR levels at the cell surface, and potentiators to allow the effective opening of the CFTR channel. Combined, these activities allow chloride ion transport yielding improved hydration of the lung surface and subsequent restoration of mucociliary clearance. . CFTR-related . manifestations. Valentina . Shakhnovich. 1. , . Lakshmi . Katta. 2. , . Kathy . Christenson. 1. , . Julie . Bass. 1. , . Emily . Farrow. 1. , . Sarah . Soden. 1. , . Laurie . Smith. 3. Henry Purcell/Nahum Tate. “Remember me! But ah—forget my fate”. . Belinda: . “Shake . the cloud from off your brow,. Fate your wishes does allow.. Empire . growing . Pleasures . auto-suggestion, the mystery of the past, . but mainly, fate. Let’s look at these from . least. important to . most. important.. a1. The . mystery of the past is mentioned briefly in paragraphs 10 & 13. P10 is mostly about collector and societies that focus on gun relics from the past, . This program will include a discussion of investigational agents not approved by the FDA for use in the US, and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.. with Purecol (Cedarlane, ) and cultured in complete SAGM (LHC basal medium supplemented with the SAGM kit (Clonetics, Walkersville, MD) and 25 ng/ml EGF, 100 U/ml of penicillinstreptomycin, 0.07 µg/m Version 301onlineFate Core is easy to play online you dont need to rely on a Virtual TableTop VTT application at all You can rely on any video or voice chatsoftwareand augment your online experience PI: John C. Kappes, PhD. Co-PI: Zhengrong Yang, PhD. Funded by the Cystic Fibrosis Foundation. C. ystic . F. ibrosis . T. ransmembrane Conductance . R. egulator (CFTR) is an ABC transporter-class ion channel protein that regulates chloride conductance across epithelial cell membranes. ObjectivesUnderstand the genetic abnormality causing cystic fibrosis (CF) and the newborn screen processRecognize the multiple organ systems affected by CFIdentify common treatments /medications and m . 2021. . . [doi]. All icons above are . courtesy of Jonathan K. Ramsey, MD. . CFTR Modulator Use is Associated with Reduced Acute Pancreatitis Hospitalizations. Population. Outcome. Conclusion. Cystic fibrosis patients with CFTR modulator exposure in MarketScan (n=1,795).

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