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#5/\bᰀᜀ#0ἀሀᰀᜀ$ᨀ/Ѐᰀᰀ(/က 3ᰀ,ᨀ/฀%0ᜀ, &ᨀ/Ԁ$ᰀ,Ḁᰀ%ᤀ5/ༀἀ5- ᤀ ᜀ%/ᜀ0/Ѐᰀᰀ(က 3ᰀ,/ᜀ%ᬀ/Ѐ -0, ᤀ0/\b&-( 0ᜀ#ᨀ/ᜀ%ᬀ/Ā-- -0ᜀ%0/ༀ,&ᴀᰀ--&,/ᜀ0\r&,0ἀᰀ,%/฀%0ᜀ, &/ᄀᤀἀ&&#/&ᴀ/\fᰀᬀ ᤀ %ᰀᨀ/ᄀ2ᬀ᠀2,5ᨀ/฀%0ᜀ, &+ rhinitis, AVAMYSreduced Total Nasal Symptom Scores rTNSSrTNSSTotal Ocular Symptom Scores (rTOSS) vs. placebo..Reductions in daily rTNSS: AVAMYS-4.94 vs. lacebo -3.18, reductions in daily rTOSS: VAMYS-3.00 vs. placebo -2.26, VAMYSymptoms in patients 12 years of age and older and or the treatment of seasonal and perennial allergic hinitis in pediatric patients 2 to . VAMYSis contraindicated in patients with a hyper-sensitivity to any of its ingredients.The most common adverse events observed in adults/dolescents with seasonal or perennial allergic rhinitis treated with AVAMYSere:9%/8%9%/8%8%/5%8%/5% 3%/1%3%/1% nasal septum 1%/1%/2%/2%2%/2% 1%/1%/ upper respiratory tract infection1%/1%1%/1%1%/1%/ In a 1-year study n adults/adolescents, adverse events were similar n type and rate between AVAMYSand placebo. roup receiving AVAMYS vs. placebo (20% vs. 8%, espectively) and was of mild intensity in the majorityof patients (AVAMYS: 83/123; placebo: 17/17).The most common adverse events observed in childrenwith AVAMYS 55 mcg/AVAMYS 110 mcg/placebo were:8%/8%/7%8%/8%/7% nasopharyngitis 5%/5%/5%5%/5%/5%5%/4%/4%5%/4%/4% pyrexia 5%/4%/2%5%/4%/2%4%/3%/3%4%/3%/3% 3%/4%/3%3%/4%/3%3%/2%/3%3%/2%/3%Avoid use in patients with recent nasal ulcers, nasal surgery, or nasal trauma. There is no evidence of HPA axis suppression following12 months12 monthsAVAMYSWhen intranasal steroids are used at higher than recommended dosages or in susceptible individuals at recommended dosages, systemic corticosteroid effects may occur such as hypercorticism, suppressionof HPA function, and/or reduction of growth velocity in children or teenagers. A phase IV clinical trial to evaluate the effect of AVAMYSgrowth in pediatric patients. Physicians should closelymonitor the growth of children taking corticosteroids.metabolized by CYP3A4, co-administration with ritonavir is not recommended. and new infections may appear. Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex may occur. Nasal and inhaled corticosteroids may result in the development of glaucoma and/or cataracts. Close monitoring is warranted in patients with a change pressure, glaucoma, and/or cataracts.* Study #FFR103184. A 2-week, randomized, double-blind, parallel-group, multicentre, placebo-controlled studycomparing AVAMYS=141) vs. placebo (=144) in patients with seasonal allergic rhinitis. REFERENCE: 1. Product Monograph of AVAMYS. GlaxoSmithKline Inc. September, 2011. AVAMYSby GlaxoSmithKline Inc. © 2012 GlaxoSmithKline Inc. All rights reserved. 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