OFFICE OF FORENSIC TOXICOLOGY SERVICES PRETRIAL SERVICES AGENCY FOR THE DISTRICT OF COLUMBIA Compounds that mimic effect of THC Bind to same receptors as THC Originally developed by research scientists and pharmaceutical companies in 1980s ID: 1041400
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1. Synthetic CannabinoidsLaboratory PerspectiveOFFICE OF FORENSIC TOXICOLOGY SERVICESPRETRIAL SERVICES AGENCY FOR THE DISTRICT OF COLUMBIA
2. Compounds that mimic effect of THCBind to same receptors as THC Originally developed by research scientists and pharmaceutical companies in 1980sAbuse first showed up in Europe about 2004Gained popularity in U.S. starting in 2010Now a major problem socially, legally and analyticallySynthetic Cannabinoids
3. Scientist/Companies John W. Huffman (JWH series)Rapheal Mechoulam (Hebrew University – HU-210)Pfizer (Charles Pfizer) CP seriesAbbott (Alexandros Makriyannis) AM seriesIllicit SourcesAsia, Europe, and South AmericaSome Synthetic Cannabinoids (SC) were named after researchers. (eg: JWH-018 are the initials of John W. Huffman)Synthetic Cannabinoids
4. Structures of some synthetic cannabinoids
5. Prevalence of synthetic cannabinoidsProduct changes rapidly; newer varieties being addedCurrent Synthetic Cannabinoids being detectedUR-144 and XLR-11 metabolitesMinor JWH-018, JWH-073, AM-2201 metabolitesAB Chminaca Metab, AB Fubinaca Metab, ADB Pinaca Metab, 5F-AB Pinaca Metab, AB Adbica MetabSynthetic Cannabinoids
6. Analytical challengesScreening limitationsDrugs are a moving targetDevelopment time too long in most casesPSA Started Screening ALL specimens for SC – October 1, 2015GC/MS limitationsLack of analytical support dataTime consumingLC/MS/MSMethod of choiceExpensiveSteep learning curveSynthetic Cannabinoids
7. Synthetic cannabinoids Trend Chart
8. Felix Adatsi, Ph.D. Director, Office of Forensic Toxicology ServicesPretrial Services Agency for the District of Columbia90 K Street, NESuite 102Washington, DC 20530(202) 585-7259Email: Felix.Adatsi@psa.govContact Information
9. Mikal Roc M.S.Immunoassay Unit SupervisorPretrial Services Agency for the District of Columbia90 K Street, NESuite 102Washington, DC 20530202-585-7263Email: Mikal.Roc@psa.govContact Information
10. Jerome J. RobinsonDirector, Office of Forensic ResearchPretrial Services Agency for D.C.90 K Street, NESuite 102Washington, DC 20530Office: 202-585-7254Email: Jerome.Robinson@psa.govContact Information