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Your Health in a Breath
Presentation on theme: "Your Health in a Breath"— Presentation transcript:
Your Health in a Breath
International Conference on Health, Healthcare and Eco-civilisation Thomas Lundeberg 托马斯•兰德伯格A novel technique for the assessment of volatile organic compounds in the environment and in human breath 评价环境和人类呼吸中挥发性有机化合物的一项新技术
Trends in healthcareGrowing world populationAging world population
Demand for increased health careIncrease of diseases like cancer, diabetes, obesity and COPDNeed for faster, better, cost-effective diagnostic methods
…beyond conventional laboratory medicine…
This is already happening
The Wall Street Journal October 9th , 2012The concept goes back to Hippocrates, who wrote a treatise on breath aroma and disease around 400 B.C. It's the ultimate noninvasive medical test: A growing number of health problems can be diagnosed by analyzing a patient's breath alone.
"Anything you can have a blood test for, there is potentially a breath test for, as long as there is a volatile - capable of readily changing from a solid or liquid form to a vapor – component.
eep Ultra Violet Analyzer
Spectrum in the deep ultra violet range [125-330] nm
Sequential analysis of different VOCs
”Non destructive” analysis of VOCs – compared to MS
Measurable quantity of original substance – down to
Pre analytic phaseSample collection
As little as half a liter of exhaled air sampled in a “plastic” bag is enough to detect chemical substances that originates from tissues.This kind of sample collection is already used today for a number of standard laboratory tests, in example for detection of Helicobacter pylori (ulcer)
Pre analytic phaseSample extraction
SPME: Solid-phase microextractionThe needle is inserted into the plastic bag and VOCs are captured in the fiber.Fast and simple procedure
Pre analytic phasePre-processing
Gas chromatography: all substances are sequentially separated in gas phase in order of boiling point/vaporized pressure. Helium or Nitrogen are used as gas carriersThe SPME is inserted in the chromatograph and gas is injected in the system
The absorbance spectrum is measured and recorded in the DUVA control centerThe data is post-processed and matched witha database of VOCs
spectrum of over 1300 VOCs
DetectionBritish Journal of Surgery
, January 2013“Exhaled volatile organic compounds identify patients with colorectal cancer” Gas-chromatography mass-spectroscopy 15 compounds identified 37 patients Overall accuracy of 76%
DetectionCancer Medicine, February 2014
“Exhaled volatile organic compounds identify patients with lung cancer” Early detection is a key factor for increasing survival 4 compounds identified in 97 patients late stages (II-IV) had higher levels
Overall accuracy of 83
Distributed test instruments Central data base
One instrument type
for multiple health checks for future medical care
Early detection of lung cancer Early detection of colorectal cancer Treatment assessment
Your Health in a Breath - Description
International Conference on Health Healthcare and Eco civilisation Thomas Lundeberg 托马斯 兰德伯格 ID: 814848 Download
Baltimore . County . Health Care Forum . Carmela Coyle. October 18, . 2016. Environmental. and Social. Factors. 20%. Family History and Genetics. 30%. Personal Behaviors . 40%. Source: Determinants of Health and Their Contribution to Premature Death, JAMA.
In the past few years the fear of bad breath has overtaken American society with the help of hundreds of new advertisements for breath mints candies gums mouthwashes and toothpastes In the past year Americans spent an amazing 3 Billion on re medies
It affects about one in 20 children This event is distressing and frightening to witness but does not cause any shortterm or longterm harm to your child Boys and girls are equally affected The spells usually start before 18 months of age and stop by
It is used for people with weakness of the muscles used for breathing A piece of equipment called a modified ambu bag is used to help push more air into the lungs as you breathe in Benefits of breath stacking x Keeps the lung clear of secretions x H
Know . When to See a Physician. Stuart Rich, M.D.. Professor of Medicine. Director, Pulmonary Vascular Disease Program. Bluhm Cardiovascular Institute. Northwestern Memorial Hospital. How we normally breathe.
MORNING REPORT HPI CC: 70 y/o w/ shortness of breath x ~1month 70 y/o Caucasian male with a history of HTN, HLD, DM, BPH, ED, and recently diagnosed polyclonal hypergammaglobulinemia presents with shortness of breath, fatigue, and lightheadedness. Symptoms began over month ago with worsening over the past two weeks. He was treated for community acquired pneumonia about a month ago with Azithromycin. He felt a little better while on the ABX but now feels about the same. He endorses shortness of breath, lightheadedness, substernal non-radiating chest pain associated with the shortness of breath, palpitations, feeling easily fatigued, feeling cold, and night sweats. Denies syncopal episodes, subjective fevers, easy bruising, headache, wheeze, cough, sputum production, Abd pain, N/V/Constipation, dysuria, and swelling.